Human papillomavirus Type 2 DNA in oral verrucous carcinoma

K. Adler‐Storthz, J. R. Newland, B. A. Tessin, W. A. Yeudall, E. J. Shillitoe

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalJournal of Oral Pathology & Medicine
Volume15
Issue number9
DOIs
StatePublished - Oct 1986

Fingerprint

Verrucous Carcinoma
DNA
Antigens
DNA Probes
In Situ Hybridization
Staining and Labeling
Viruses
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Human papillomavirus Type 2 DNA in oral verrucous carcinoma. / Adler‐Storthz, K.; Newland, J. R.; Tessin, B. A.; Yeudall, W. A.; Shillitoe, E. J.

In: Journal of Oral Pathology & Medicine, Vol. 15, No. 9, 10.1986, p. 472-475.

Research output: Contribution to journalArticle

Adler‐Storthz, K. ; Newland, J. R. ; Tessin, B. A. ; Yeudall, W. A. ; Shillitoe, E. J. / Human papillomavirus Type 2 DNA in oral verrucous carcinoma. In: Journal of Oral Pathology & Medicine. 1986 ; Vol. 15, No. 9. pp. 472-475.
@article{52b7e9f86e944d4780e0dcc32f247c78,
title = "Human papillomavirus Type 2 DNA in oral verrucous carcinoma",
abstract = "Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.",
author = "K. Adler‐Storthz and Newland, {J. R.} and Tessin, {B. A.} and Yeudall, {W. A.} and Shillitoe, {E. J.}",
year = "1986",
month = "10",
doi = "10.1111/j.1600-0714.1986.tb00661.x",
language = "English (US)",
volume = "15",
pages = "472--475",
journal = "Journal of Oral Pathology and Medicine",
issn = "0904-2512",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Human papillomavirus Type 2 DNA in oral verrucous carcinoma

AU - Adler‐Storthz, K.

AU - Newland, J. R.

AU - Tessin, B. A.

AU - Yeudall, W. A.

AU - Shillitoe, E. J.

PY - 1986/10

Y1 - 1986/10

N2 - Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.

AB - Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.

UR - http://www.scopus.com/inward/record.url?scp=0022800462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022800462&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0714.1986.tb00661.x

DO - 10.1111/j.1600-0714.1986.tb00661.x

M3 - Article

C2 - 3027288

AN - SCOPUS:0022800462

VL - 15

SP - 472

EP - 475

JO - Journal of Oral Pathology and Medicine

JF - Journal of Oral Pathology and Medicine

SN - 0904-2512

IS - 9

ER -