Although this patient met clinical and laboratory criteria for the diagnosis of XLA, his mother does not appear to be an XLA carrier. He thus has a congenital agammaglobulinemia which cannot be classified by current criteria. When possible, X chromosome inactivation studies should be performed in mothers of patients believed to have XLA, not only for purposes of genetic counseling, but also for better understanding and more accurate classification of this clinically, immunologically, and genetically heterogeneous group of disorders.
|Original language||English (US)|
|Journal||Annals of Allergy|
|State||Published - Jan 1 1989|
ASJC Scopus subject areas
- Immunology and Allergy