TY - JOUR
T1 - Hyalinizing clear cell carcinoma of the head and neck
T2 - Case series and update
AU - Albergotti, W. Greer
AU - Bilodeau, Elizabeth A.
AU - Byrd, J. Kenneth
AU - Mims, Mark M.
AU - Lee, Stella
AU - Kim, Seungwon
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background Hyalinizing clear cell carcinoma (HCCC) is a rare neoplasm of salivary gland origin which is low-grade in nature. In this series, we report on 9 cases of HCCC and update the literature. Methods A comprehensive literature search was performed. Our institutional database was queried for cases of HCCC. Pathology reports and slides were reviewed. Data was extracted, including demographics, staging, primary treatment, histopathologic findings, recurrence, and disease status. Statistical analysis was performed using a Pearson's chi-square test. Results One hundred thirty-six total cases were included for analysis. The overall recurrence rate was 19.8%. Necrosis was associated with risk of recurrence (p =.003). Positive margins and lymph node status were associated with risk of recurrence. Prognosis was good with only 3 of 82 patients reported dying with disease. Conclusion HCCC has an overall good prognosis with potential for aggressive behavior. The presence of necrosis, locoregional disease, or positive margins is associated with risk for recurrence.
AB - Background Hyalinizing clear cell carcinoma (HCCC) is a rare neoplasm of salivary gland origin which is low-grade in nature. In this series, we report on 9 cases of HCCC and update the literature. Methods A comprehensive literature search was performed. Our institutional database was queried for cases of HCCC. Pathology reports and slides were reviewed. Data was extracted, including demographics, staging, primary treatment, histopathologic findings, recurrence, and disease status. Statistical analysis was performed using a Pearson's chi-square test. Results One hundred thirty-six total cases were included for analysis. The overall recurrence rate was 19.8%. Necrosis was associated with risk of recurrence (p =.003). Positive margins and lymph node status were associated with risk of recurrence. Prognosis was good with only 3 of 82 patients reported dying with disease. Conclusion HCCC has an overall good prognosis with potential for aggressive behavior. The presence of necrosis, locoregional disease, or positive margins is associated with risk for recurrence.
KW - EWSR1
KW - clear cell carcinoma
KW - head and neck cancer
KW - hyalinizing clear cell carcinoma
KW - salivary gland cancer
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U2 - 10.1002/hed.23902
DO - 10.1002/hed.23902
M3 - Article
C2 - 25352039
AN - SCOPUS:84958107208
SN - 1043-3074
VL - 38
SP - 426
EP - 433
JO - Head and Neck
JF - Head and Neck
IS - 3
ER -