Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh; Sepideh Mirzaei; Mohammad Hossein Gholami; Farid Hashemi; Amirhossein Zabolian; Mehdi Raei; Kiavash Hushmandi; Ali Zarrabi; Nicolas H. Voelcker; Amir Reza Aref; Michael R. Hamblin; Rajender S. Varma; Saeed Samarghandian; I. J. Arostegi; M. Alzola; Alan Prem Kumar; Vijay Kumar Thakur; Noushin Nabavi; Pooyan Makvandi; Franklin R. Tay; Gorka Orive

doi:10.1016/j.carbpol.2021.118491

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh, Sepideh Mirzaei, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Mehdi Raei, Kiavash Hushmandi, Ali Zarrabi, Nicolas H. Voelcker, Amir Reza Aref, Michael R. Hamblin, Rajender S. Varma, Saeed Samarghandian, I. J. Arostegi, M. Alzola, Alan Prem Kumar, Vijay Kumar Thakur, Noushin Nabavi, Pooyan Makvandi, Franklin R. TayGorka Orive

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

Abstract

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

Original language	English (US)
Article number	118491
Journal	Carbohydrate Polymers
Volume	272
DOIs	https://doi.org/10.1016/j.carbpol.2021.118491
State	Published - Nov 15 2021

Keywords

CD44
Doxorubicin
Drug resistance
Endocytosis
Hyaluronic acid
Nanodelivery system
Theranostic

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.carbpol.2021.118491

Cite this

Ashrafizadeh, M., Mirzaei, S., Gholami, M. H., Hashemi, F., Zabolian, A., Raei, M., Hushmandi, K., Zarrabi, A., Voelcker, N. H., Aref, A. R., Hamblin, M. R., Varma, R. S., Samarghandian, S., Arostegi, I. J., Alzola, M., Kumar, A. P., Thakur, V. K., Nabavi, N., Makvandi, P., ... Orive, G. (2021). Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression. Carbohydrate Polymers, 272, Article 118491. https://doi.org/10.1016/j.carbpol.2021.118491

Ashrafizadeh, M, Mirzaei, S, Gholami, MH, Hashemi, F, Zabolian, A, Raei, M, Hushmandi, K, Zarrabi, A, Voelcker, NH, Aref, AR, Hamblin, MR, Varma, RS, Samarghandian, S, Arostegi, IJ, Alzola, M, Kumar, AP, Thakur, VK, Nabavi, N, Makvandi, P, Tay, FR & Orive, G 2021, 'Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression', Carbohydrate Polymers, vol. 272, 118491. https://doi.org/10.1016/j.carbpol.2021.118491

@article{7b7ea2d2e9564afdbc94d6cb730b1816,

title = "Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression",

abstract = "An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.",

keywords = "CD44, Doxorubicin, Drug resistance, Endocytosis, Hyaluronic acid, Nanodelivery system, Theranostic",

author = "Milad Ashrafizadeh and Sepideh Mirzaei and Gholami, {Mohammad Hossein} and Farid Hashemi and Amirhossein Zabolian and Mehdi Raei and Kiavash Hushmandi and Ali Zarrabi and Voelcker, {Nicolas H.} and Aref, {Amir Reza} and Hamblin, {Michael R.} and Varma, {Rajender S.} and Saeed Samarghandian and Arostegi, {I. J.} and M. Alzola and Kumar, {Alan Prem} and Thakur, {Vijay Kumar} and Noushin Nabavi and Pooyan Makvandi and Tay, {Franklin R.} and Gorka Orive",

note = "Funding Information: Grant from the Ministry of Education - Singapore ( MOE-T2EP30120-0016 ) supported APK. The National Research Foundation Singapore and the Singapore Ministry of Education under its Research Center of Excellence initiative to Cancer Science Institute of Singapore ; National University of Singapore also supported APK. GO wish to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. Figs. 1 and 2 were drawn by Biorender (Biorender.com). Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = nov,

day = "15",

doi = "10.1016/j.carbpol.2021.118491",

language = "English (US)",

volume = "272",

journal = "Carbohydrate Polymers",

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publisher = "Elsevier Limited",

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TY - JOUR

T1 - Hyaluronic acid-based nanoplatforms for Doxorubicin

T2 - A review of stimuli-responsive carriers, co-delivery and resistance suppression

AU - Ashrafizadeh, Milad

AU - Mirzaei, Sepideh

AU - Gholami, Mohammad Hossein

AU - Hashemi, Farid

AU - Zabolian, Amirhossein

AU - Raei, Mehdi

AU - Hushmandi, Kiavash

AU - Zarrabi, Ali

AU - Voelcker, Nicolas H.

AU - Aref, Amir Reza

AU - Hamblin, Michael R.

AU - Varma, Rajender S.

AU - Samarghandian, Saeed

AU - Arostegi, I. J.

AU - Alzola, M.

AU - Kumar, Alan Prem

AU - Thakur, Vijay Kumar

AU - Nabavi, Noushin

AU - Makvandi, Pooyan

AU - Tay, Franklin R.

AU - Orive, Gorka

N1 - Funding Information: Grant from the Ministry of Education - Singapore ( MOE-T2EP30120-0016 ) supported APK. The National Research Foundation Singapore and the Singapore Ministry of Education under its Research Center of Excellence initiative to Cancer Science Institute of Singapore ; National University of Singapore also supported APK. GO wish to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. Figs. 1 and 2 were drawn by Biorender (Biorender.com). Publisher Copyright: © 2021 The Author(s)

PY - 2021/11/15

Y1 - 2021/11/15

N2 - An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

AB - An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

KW - CD44

KW - Doxorubicin

KW - Drug resistance

KW - Endocytosis

KW - Hyaluronic acid

KW - Nanodelivery system

KW - Theranostic

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U2 - 10.1016/j.carbpol.2021.118491

DO - 10.1016/j.carbpol.2021.118491

M3 - Review article

C2 - 34420747

AN - SCOPUS:85111936989

SN - 0144-8617

VL - 272

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 118491

ER -

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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