Abstract
Hyaluronic acid (HA) was crosslinked with Gd(III) and Fe(III) ions rendering physically crosslinked HA-metal(III) microgels as magnetic resonance imaging (MRI) enhancing contrast agents. These HA-Gd(III) and HA-Fe(III) microgels are injectable with size range, 50–5000 nm in water. The same isoelectric point, pH 1.2 ± 0.1, was measured for both microgels. HA-Gd(III) and HA-Fe(III) microgels are hemo-compatible biomaterials and can be safely used in intravascular applications up to 1000 μg/mL concentration. Furthermore, no significant toxicity was attained as 95 ± 8 and 81 ± 2% cell viability on L929 fibroblast cells at 100 μg/mL of HA-Gd(III) and HA-Fe(III) microgels were measured. Moreover, HA-Gd(III) microgels were found to afford significant contrast improvement capability in MRI with proton relaxivity, r1 = 2.11 mM−1 s−1, comparable with the values reported for Gd(III) labeled functionalized HA gel systems and commercial Gd based contrast agents.
Original language | English (US) |
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Article number | 118873 |
Pages (from-to) | 118873 |
Journal | Carbohydrate Polymers |
Volume | 277 |
DOIs | |
State | Published - Feb 1 2022 |
Externally published | Yes |
Keywords
- Blood compatible
- Fe(II) chelating
- HA-Fe(III) microgel
- HA-Gd(III) microgel
- Hyaluronic acid (HA)
- Magnetic resonance imaging (MRI)
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry