Hyaluronsäure und hyaluronidase. Zwei neue blasenkarzinommarker

S. H. Hautmann; G. L. Schroeder; F. Civantos; R. C. Duncan; R. Gnann; M. G. Friedrich; A. Hellstern; H. Huland; M. S. Soloway; V. B. Lokeshwar

doi:10.1007/s001200050449

Hyaluronsäure und hyaluronidase. Zwei neue blasenkarzinommarker

Translated title of the contribution: Hyaluronic acid and hyaluronidase. Two new markers for bladder cancer

S. H. Hautmann, G. L. Schroeder, F. Civantos, R. C. Duncan, R. Gnann, M. G. Friedrich, A. Hellstern, H. Huland, M. S. Soloway, V. B. Lokeshwar

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The heterogeneity of bladder cancer concerning progress or recurrence is an essential characteristic of this disease. Hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are intricately associated with bladder cancer angiogenesis and metastasis. Tumor-associated HA and HAase are secreted in urine. In 513 urine specimens (261 bladder cancer patients, 252 patients without bladder cancer) and 83 bladder tissue specimens (71 bladder tumors, 12 normal bladder tissues), the accuracy of HA and HAase as tumor markers was studied. Elevated urinary HA levels (≥500 ng/ml), indicating a positive HA test, suggest the presence of bladder cancer regardless of tumor grade. Elevated urinary HAase levels (≥10 mU/mg) indicate high-grade (G2/G3) bladder cancer. The combined HA-HAase urine test showed 91% sensitivity and 84% specificity to detect bladder cancer. The HA-HAase test is equally sensitive for monitoring tumor recurrence. Immunohistochemistry (IHC) staining of HA and HAase in the G1 and G2/G3 bladder cancer specimens was significantly (p<0.001) higher than in normal bladder tissue. HA and HAase appear to be useful markers in the diagnosis of bladder cancer. When compared with other noninvasive tests, the HA-HAase urine test may be less expensive and more accurate.

Translated title of the contribution	Hyaluronic acid and hyaluronidase. Two new markers for bladder cancer
Original language	German
Pages (from-to)	121-126
Number of pages	6
Journal	Urologe - Ausgabe A
Volume	40
Issue number	2
DOIs	https://doi.org/10.1007/s001200050449
State	Published - 2001
Externally published	Yes

Keywords

Bladder cancer
Diagnostics
Hyaluronic acid
Hyaluronidase
Tumor marker

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s001200050449

Cite this

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title = "Hyalurons{\"a}ure und hyaluronidase. Zwei neue blasenkarzinommarker",

abstract = "The heterogeneity of bladder cancer concerning progress or recurrence is an essential characteristic of this disease. Hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are intricately associated with bladder cancer angiogenesis and metastasis. Tumor-associated HA and HAase are secreted in urine. In 513 urine specimens (261 bladder cancer patients, 252 patients without bladder cancer) and 83 bladder tissue specimens (71 bladder tumors, 12 normal bladder tissues), the accuracy of HA and HAase as tumor markers was studied. Elevated urinary HA levels (≥500 ng/ml), indicating a positive HA test, suggest the presence of bladder cancer regardless of tumor grade. Elevated urinary HAase levels (≥10 mU/mg) indicate high-grade (G2/G3) bladder cancer. The combined HA-HAase urine test showed 91% sensitivity and 84% specificity to detect bladder cancer. The HA-HAase test is equally sensitive for monitoring tumor recurrence. Immunohistochemistry (IHC) staining of HA and HAase in the G1 and G2/G3 bladder cancer specimens was significantly (p<0.001) higher than in normal bladder tissue. HA and HAase appear to be useful markers in the diagnosis of bladder cancer. When compared with other noninvasive tests, the HA-HAase urine test may be less expensive and more accurate.",

keywords = "Bladder cancer, Diagnostics, Hyaluronic acid, Hyaluronidase, Tumor marker",

author = "Hautmann, {S. H.} and Schroeder, {G. L.} and F. Civantos and Duncan, {R. C.} and R. Gnann and Friedrich, {M. G.} and A. Hellstern and H. Huland and Soloway, {M. S.} and Lokeshwar, {V. B.}",

year = "2001",

doi = "10.1007/s001200050449",

language = "German",

volume = "40",

pages = "121--126",

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T1 - Hyaluronsäure und hyaluronidase. Zwei neue blasenkarzinommarker

AU - Hautmann, S. H.

AU - Schroeder, G. L.

AU - Civantos, F.

AU - Duncan, R. C.

AU - Gnann, R.

AU - Friedrich, M. G.

AU - Hellstern, A.

AU - Huland, H.

AU - Soloway, M. S.

AU - Lokeshwar, V. B.

PY - 2001

Y1 - 2001

N2 - The heterogeneity of bladder cancer concerning progress or recurrence is an essential characteristic of this disease. Hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are intricately associated with bladder cancer angiogenesis and metastasis. Tumor-associated HA and HAase are secreted in urine. In 513 urine specimens (261 bladder cancer patients, 252 patients without bladder cancer) and 83 bladder tissue specimens (71 bladder tumors, 12 normal bladder tissues), the accuracy of HA and HAase as tumor markers was studied. Elevated urinary HA levels (≥500 ng/ml), indicating a positive HA test, suggest the presence of bladder cancer regardless of tumor grade. Elevated urinary HAase levels (≥10 mU/mg) indicate high-grade (G2/G3) bladder cancer. The combined HA-HAase urine test showed 91% sensitivity and 84% specificity to detect bladder cancer. The HA-HAase test is equally sensitive for monitoring tumor recurrence. Immunohistochemistry (IHC) staining of HA and HAase in the G1 and G2/G3 bladder cancer specimens was significantly (p<0.001) higher than in normal bladder tissue. HA and HAase appear to be useful markers in the diagnosis of bladder cancer. When compared with other noninvasive tests, the HA-HAase urine test may be less expensive and more accurate.

AB - The heterogeneity of bladder cancer concerning progress or recurrence is an essential characteristic of this disease. Hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are intricately associated with bladder cancer angiogenesis and metastasis. Tumor-associated HA and HAase are secreted in urine. In 513 urine specimens (261 bladder cancer patients, 252 patients without bladder cancer) and 83 bladder tissue specimens (71 bladder tumors, 12 normal bladder tissues), the accuracy of HA and HAase as tumor markers was studied. Elevated urinary HA levels (≥500 ng/ml), indicating a positive HA test, suggest the presence of bladder cancer regardless of tumor grade. Elevated urinary HAase levels (≥10 mU/mg) indicate high-grade (G2/G3) bladder cancer. The combined HA-HAase urine test showed 91% sensitivity and 84% specificity to detect bladder cancer. The HA-HAase test is equally sensitive for monitoring tumor recurrence. Immunohistochemistry (IHC) staining of HA and HAase in the G1 and G2/G3 bladder cancer specimens was significantly (p<0.001) higher than in normal bladder tissue. HA and HAase appear to be useful markers in the diagnosis of bladder cancer. When compared with other noninvasive tests, the HA-HAase urine test may be less expensive and more accurate.

KW - Bladder cancer

KW - Diagnostics

KW - Hyaluronic acid

KW - Hyaluronidase

KW - Tumor marker

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Hyaluronsäure und hyaluronidase. Zwei neue blasenkarzinommarker

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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