Hyaluronsäure und hyaluronidase. Zwei neue blasenkarzinommarker

Translated title of the contribution: Hyaluronic acid and hyaluronidase. Two new markers for bladder cancer

S. H. Hautmann, G. L. Schroeder, F. Civantos, R. C. Duncan, R. Gnann, M. G. Friedrich, A. Hellstern, H. Huland, M. S. Soloway, V. B. Lokeshwar

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The heterogeneity of bladder cancer concerning progress or recurrence is an essential characteristic of this disease. Hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are intricately associated with bladder cancer angiogenesis and metastasis. Tumor-associated HA and HAase are secreted in urine. In 513 urine specimens (261 bladder cancer patients, 252 patients without bladder cancer) and 83 bladder tissue specimens (71 bladder tumors, 12 normal bladder tissues), the accuracy of HA and HAase as tumor markers was studied. Elevated urinary HA levels (≥500 ng/ml), indicating a positive HA test, suggest the presence of bladder cancer regardless of tumor grade. Elevated urinary HAase levels (≥10 mU/mg) indicate high-grade (G2/G3) bladder cancer. The combined HA-HAase urine test showed 91% sensitivity and 84% specificity to detect bladder cancer. The HA-HAase test is equally sensitive for monitoring tumor recurrence. Immunohistochemistry (IHC) staining of HA and HAase in the G1 and G2/G3 bladder cancer specimens was significantly (p<0.001) higher than in normal bladder tissue. HA and HAase appear to be useful markers in the diagnosis of bladder cancer. When compared with other noninvasive tests, the HA-HAase urine test may be less expensive and more accurate.

Translated title of the contributionHyaluronic acid and hyaluronidase. Two new markers for bladder cancer
Original languageGerman
Pages (from-to)121-126
Number of pages6
JournalUrologe - Ausgabe A
Issue number2
StatePublished - 2001
Externally publishedYes


  • Bladder cancer
  • Diagnostics
  • Hyaluronic acid
  • Hyaluronidase
  • Tumor marker

ASJC Scopus subject areas

  • Urology


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