Hydroxyurea adherence strategies for persons with sickle cell disease: A systematic review

Lori Vick; Maryellen Potts; Megan Jaskowiak; Robert W. Gibson

doi:10.1353/hpu.2021.0011

Hydroxyurea adherence strategies for persons with sickle cell disease: A systematic review

Lori Vick, Maryellen Potts, Megan Jaskowiak, Robert W. Gibson

Emergency Medicine and Hospitalist Services

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Introduction. Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease. Objective. To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease. Methods. A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018. Results. Six studies met inclusion criteria: two randomized controlled trials, three prospective studies, and one retrospective chart review. Discussion. Few studies addressed strategies that tested adherence interventions primarily composed of behavioral change resulting in medication adherence. More studies on hydroxyurea adherence are needed.

Original language	English (US)
Pages (from-to)	99-118
Number of pages	20
Journal	Journal of Health Care for the Poor and Underserved
Volume	32
Issue number	1
DOIs	https://doi.org/10.1353/hpu.2021.0011
State	Published - 2021

Keywords

Adherence
Hydroxyurea
Medication
Sickle cell

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1353/hpu.2021.0011

Cite this

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title = "Hydroxyurea adherence strategies for persons with sickle cell disease: A systematic review",

abstract = "Introduction. Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease. Objective. To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease. Methods. A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018. Results. Six studies met inclusion criteria: two randomized controlled trials, three prospective studies, and one retrospective chart review. Discussion. Few studies addressed strategies that tested adherence interventions primarily composed of behavioral change resulting in medication adherence. More studies on hydroxyurea adherence are needed.",

keywords = "Adherence, Hydroxyurea, Medication, Sickle cell",

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T1 - Hydroxyurea adherence strategies for persons with sickle cell disease

T2 - A systematic review

AU - Vick, Lori

AU - Potts, Maryellen

AU - Jaskowiak, Megan

AU - Gibson, Robert W.

N1 - Publisher Copyright: © Meharry Medical College.

PY - 2021

Y1 - 2021

N2 - Introduction. Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease. Objective. To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease. Methods. A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018. Results. Six studies met inclusion criteria: two randomized controlled trials, three prospective studies, and one retrospective chart review. Discussion. Few studies addressed strategies that tested adherence interventions primarily composed of behavioral change resulting in medication adherence. More studies on hydroxyurea adherence are needed.

AB - Introduction. Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease. Objective. To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease. Methods. A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018. Results. Six studies met inclusion criteria: two randomized controlled trials, three prospective studies, and one retrospective chart review. Discussion. Few studies addressed strategies that tested adherence interventions primarily composed of behavioral change resulting in medication adherence. More studies on hydroxyurea adherence are needed.

KW - Adherence

KW - Hydroxyurea

KW - Medication

KW - Sickle cell

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Hydroxyurea adherence strategies for persons with sickle cell disease: A systematic review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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