Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

Adviye Ergul; Weiguo Li; Mostafa M. Elgebaly; Askiel Bruno; Susan C. Fagan

doi:10.1016/j.vph.2009.02.004

Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

Adviye Ergul, Weiguo Li, Mostafa M. Elgebaly, Askiel Bruno, Susan C. Fagan

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Acute ischemic stroke (AIS) results from the occlusion of an artery and causes vascular and neuronal damage, both of which affect the extent of ischemic injury and stroke outcome. Despite extensive efforts, there is only one effective treatment for AIS. Given that up to 40% of the AIS patients present with admission hyperglycemia either as a result of diabetes or acute stress response, targets for neuronal and vascular protection under hyperglycemic conditions need to be better defined. Here, we review the impact of diabetes and acute hyperglycemia on experimental stroke with an emphasis on cerebrovasculature structure and function. The relevance to clinical evidence is also discussed.

Original language	English (US)
Pages (from-to)	44-49
Number of pages	6
Journal	Vascular Pharmacology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.vph.2009.02.004
State	Published - Jul 2009

Keywords

Diabetes
Hyperglycemia
Ischemia reperfusion injury
Stroke

ASJC Scopus subject areas

Physiology
Molecular Medicine
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vph.2009.02.004

Cite this

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title = "Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature",

abstract = "Acute ischemic stroke (AIS) results from the occlusion of an artery and causes vascular and neuronal damage, both of which affect the extent of ischemic injury and stroke outcome. Despite extensive efforts, there is only one effective treatment for AIS. Given that up to 40% of the AIS patients present with admission hyperglycemia either as a result of diabetes or acute stress response, targets for neuronal and vascular protection under hyperglycemic conditions need to be better defined. Here, we review the impact of diabetes and acute hyperglycemia on experimental stroke with an emphasis on cerebrovasculature structure and function. The relevance to clinical evidence is also discussed.",

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note = "Funding Information: This work was supported by grants from NIH (NS054688, DK074385) and American Heart Association Established Investigator Award to Adviye Ergul and NIH (NS044216), VA Merit Review and American Heart Association-SE affiliate to Susan C. Fagan.",

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AU - Elgebaly, Mostafa M.

AU - Bruno, Askiel

AU - Fagan, Susan C.

N1 - Funding Information: This work was supported by grants from NIH (NS054688, DK074385) and American Heart Association Established Investigator Award to Adviye Ergul and NIH (NS044216), VA Merit Review and American Heart Association-SE affiliate to Susan C. Fagan.

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N2 - Acute ischemic stroke (AIS) results from the occlusion of an artery and causes vascular and neuronal damage, both of which affect the extent of ischemic injury and stroke outcome. Despite extensive efforts, there is only one effective treatment for AIS. Given that up to 40% of the AIS patients present with admission hyperglycemia either as a result of diabetes or acute stress response, targets for neuronal and vascular protection under hyperglycemic conditions need to be better defined. Here, we review the impact of diabetes and acute hyperglycemia on experimental stroke with an emphasis on cerebrovasculature structure and function. The relevance to clinical evidence is also discussed.

AB - Acute ischemic stroke (AIS) results from the occlusion of an artery and causes vascular and neuronal damage, both of which affect the extent of ischemic injury and stroke outcome. Despite extensive efforts, there is only one effective treatment for AIS. Given that up to 40% of the AIS patients present with admission hyperglycemia either as a result of diabetes or acute stress response, targets for neuronal and vascular protection under hyperglycemic conditions need to be better defined. Here, we review the impact of diabetes and acute hyperglycemia on experimental stroke with an emphasis on cerebrovasculature structure and function. The relevance to clinical evidence is also discussed.

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KW - Ischemia reperfusion injury

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Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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