Hyperinsulinemia and cognitive decline in a middle-aged cohort

Sara Elizabeth Young, Arch G. Mainous, Mark Carnemolla

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

OBJECTIVE - Determining modifiable risks factors for cognitive decline and dementia are a public health priority as we seek to prevent dementia. Type 2 diabetes and related disorders such as hyperinsulinemia increase with aging and are increasing in the U.S. population. Our objective was to determine whether hyperinsulinemia is associated with cognitive decline among middle-aged adults without type 2 diabetes, dementia, or stroke in the Atherosclerosis Risk in Communities (ARIC) cohort. RESEARCH DESIGN AND METHODS - Middle-aged adults (aged 45-64 years at baseline) in the ARIC cohort had fasting insulin and glucose assessed between 1987 and 1989. Subjects with dementia, type 2 diabetes, or stroke at baseline were excluded from analysis. Three tests of cognitive function available at baseline and 6 years later were delayed word recall (DWR), digit symbol subtest (DSS), and first letter word fluency (WF). Cross-sectional comparisons and linear regression models were computed for cognitive tests at baseline and change in cognitive test scores to determine whether cognitive function was associated with two measures of insulin resistance, fasting insulin and homeostasis model assessment (HOMA). Linear regression models controlled for age, sex, race, marital status, education level, smoking status, alcohol use, depression, hypertension, and hyperlipidemia. RESULTS - In unadjusted and adjusted analyses, hyperinsulinemia based on fasting insulin and HOMA at baseline was associated with significantly lower baseline DWR, DSS, and WF scores and a greater decline over 6 years in DWR and WF. CONCLUSIONS - Insulin resistance is a potentially modifiable midlife risk factor for cognitive decline and dementia.

Original languageEnglish (US)
Pages (from-to)2688-2693
Number of pages6
JournalDiabetes Care
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2006

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Hyperinsulinism
Dementia
Linear Models
Type 2 Diabetes Mellitus
Fasting
Insulin
Cognition
Insulin Resistance
Atherosclerosis
Homeostasis
Stroke
Health Priorities
Marital Status
Hyperlipidemias
Research Design
Public Health
Smoking
Alcohols
Cognitive Dysfunction
Depression

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Young, S. E., Mainous, A. G., & Carnemolla, M. (2006). Hyperinsulinemia and cognitive decline in a middle-aged cohort. Diabetes Care, 29(12), 2688-2693. https://doi.org/10.2337/dc06-0915

Hyperinsulinemia and cognitive decline in a middle-aged cohort. / Young, Sara Elizabeth; Mainous, Arch G.; Carnemolla, Mark.

In: Diabetes Care, Vol. 29, No. 12, 01.12.2006, p. 2688-2693.

Research output: Contribution to journalArticle

Young, SE, Mainous, AG & Carnemolla, M 2006, 'Hyperinsulinemia and cognitive decline in a middle-aged cohort', Diabetes Care, vol. 29, no. 12, pp. 2688-2693. https://doi.org/10.2337/dc06-0915
Young, Sara Elizabeth ; Mainous, Arch G. ; Carnemolla, Mark. / Hyperinsulinemia and cognitive decline in a middle-aged cohort. In: Diabetes Care. 2006 ; Vol. 29, No. 12. pp. 2688-2693.
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