Giperoksicheskaia vazokonstriktsiia v golovnom mozgu realizuetsia putem inaktivatsii oksida azota superoksidnymi anionami.

Translated title of the contribution: Hyperoxic vasoconstriction in the brain is realized by inactivation of nitric oxide by superoxide anions

S. I. Zhiliaev, A. N. Moskvin, T. F. Platonova, Diana Raisovna Gutsaeva, I. V. Churilina, I. T. Demchenko

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We tested a hypothesis that the cerebral blood flow (CBF) is reduced at hyperbaric oxygen due to inactivation of nitric oxide (NO) by superoxide anions (O2). In our experiments, the CBF was measured under hyperbaric oxygenation (HBO) 4ATA after inhibition of NO synthesis and inactivation of O2. The CBF was reduced at HBO exposure. Inhibition of NO--synthase type I and III (NOS) by L-NAME in the air caused the same decreasing of the CBF as at 4 ATA HBO. Hyperbaric vasoconstriction was diminished after NOS inhibition. Intravenous injection of superoxide dismutase (CuZn SOD) increased the CBF in the air and HBO exposure. This effect disappeared at preliminary NOS inhibition. These data suggest that inactivation of NO by O2 is a more effective mechanism of HBO vasoconstriction.

Original languageRussian
Pages (from-to)553-559
Number of pages7
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume88
Issue number5
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Hyperbaric Oxygenation
Vasoconstriction
Superoxides
Nitric Oxide
Brain
Air
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type III
NG-Nitroarginine Methyl Ester
Intravenous Injections
Superoxide Dismutase
Oxygen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Giperoksicheskaia vazokonstriktsiia v golovnom mozgu realizuetsia putem inaktivatsii oksida azota superoksidnymi anionami. / Zhiliaev, S. I.; Moskvin, A. N.; Platonova, T. F.; Gutsaeva, Diana Raisovna; Churilina, I. V.; Demchenko, I. T.

In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, Vol. 88, No. 5, 01.01.2002, p. 553-559.

Research output: Contribution to journalArticle

@article{cf368a693f534734a39427f64704cdbe,
title = "Giperoksicheskaia vazokonstriktsiia v golovnom mozgu realizuetsia putem inaktivatsii oksida azota superoksidnymi anionami.",
abstract = "We tested a hypothesis that the cerebral blood flow (CBF) is reduced at hyperbaric oxygen due to inactivation of nitric oxide (NO) by superoxide anions (O2). In our experiments, the CBF was measured under hyperbaric oxygenation (HBO) 4ATA after inhibition of NO synthesis and inactivation of O2. The CBF was reduced at HBO exposure. Inhibition of NO--synthase type I and III (NOS) by L-NAME in the air caused the same decreasing of the CBF as at 4 ATA HBO. Hyperbaric vasoconstriction was diminished after NOS inhibition. Intravenous injection of superoxide dismutase (CuZn SOD) increased the CBF in the air and HBO exposure. This effect disappeared at preliminary NOS inhibition. These data suggest that inactivation of NO by O2 is a more effective mechanism of HBO vasoconstriction.",
author = "Zhiliaev, {S. I.} and Moskvin, {A. N.} and Platonova, {T. F.} and Gutsaeva, {Diana Raisovna} and Churilina, {I. V.} and Demchenko, {I. T.}",
year = "2002",
month = "1",
day = "1",
language = "Russian",
volume = "88",
pages = "553--559",
journal = "Fiziologicheskii Zhurnal Imeni I.M. Sechenova",
issn = "0869-8139",
publisher = "Nauka Publishers",
number = "5",

}

TY - JOUR

T1 - Giperoksicheskaia vazokonstriktsiia v golovnom mozgu realizuetsia putem inaktivatsii oksida azota superoksidnymi anionami.

AU - Zhiliaev, S. I.

AU - Moskvin, A. N.

AU - Platonova, T. F.

AU - Gutsaeva, Diana Raisovna

AU - Churilina, I. V.

AU - Demchenko, I. T.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - We tested a hypothesis that the cerebral blood flow (CBF) is reduced at hyperbaric oxygen due to inactivation of nitric oxide (NO) by superoxide anions (O2). In our experiments, the CBF was measured under hyperbaric oxygenation (HBO) 4ATA after inhibition of NO synthesis and inactivation of O2. The CBF was reduced at HBO exposure. Inhibition of NO--synthase type I and III (NOS) by L-NAME in the air caused the same decreasing of the CBF as at 4 ATA HBO. Hyperbaric vasoconstriction was diminished after NOS inhibition. Intravenous injection of superoxide dismutase (CuZn SOD) increased the CBF in the air and HBO exposure. This effect disappeared at preliminary NOS inhibition. These data suggest that inactivation of NO by O2 is a more effective mechanism of HBO vasoconstriction.

AB - We tested a hypothesis that the cerebral blood flow (CBF) is reduced at hyperbaric oxygen due to inactivation of nitric oxide (NO) by superoxide anions (O2). In our experiments, the CBF was measured under hyperbaric oxygenation (HBO) 4ATA after inhibition of NO synthesis and inactivation of O2. The CBF was reduced at HBO exposure. Inhibition of NO--synthase type I and III (NOS) by L-NAME in the air caused the same decreasing of the CBF as at 4 ATA HBO. Hyperbaric vasoconstriction was diminished after NOS inhibition. Intravenous injection of superoxide dismutase (CuZn SOD) increased the CBF in the air and HBO exposure. This effect disappeared at preliminary NOS inhibition. These data suggest that inactivation of NO by O2 is a more effective mechanism of HBO vasoconstriction.

UR - http://www.scopus.com/inward/record.url?scp=0036562314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036562314&partnerID=8YFLogxK

M3 - Article

C2 - 12136722

AN - SCOPUS:0036562314

VL - 88

SP - 553

EP - 559

JO - Fiziologicheskii Zhurnal Imeni I.M. Sechenova

JF - Fiziologicheskii Zhurnal Imeni I.M. Sechenova

SN - 0869-8139

IS - 5

ER -