Giperoksicheskaia vazokonstriktsiia v golovnom mozgu realizuetsia putem inaktivatsii oksida azota superoksidnymi anionami.

Translated title of the contribution: Hyperoxic vasoconstriction in the brain is realized by inactivation of nitric oxide by superoxide anions

S. I. Zhiliaev, A. N. Moskvin, T. F. Platonova, D. R. Gutsaeva, I. V. Churilina, I. T. Demchenko

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We tested a hypothesis that the cerebral blood flow (CBF) is reduced at hyperbaric oxygen due to inactivation of nitric oxide (NO) by superoxide anions (O2). In our experiments, the CBF was measured under hyperbaric oxygenation (HBO) 4ATA after inhibition of NO synthesis and inactivation of O2. The CBF was reduced at HBO exposure. Inhibition of NO--synthase type I and III (NOS) by L-NAME in the air caused the same decreasing of the CBF as at 4 ATA HBO. Hyperbaric vasoconstriction was diminished after NOS inhibition. Intravenous injection of superoxide dismutase (CuZn SOD) increased the CBF in the air and HBO exposure. This effect disappeared at preliminary NOS inhibition. These data suggest that inactivation of NO by O2 is a more effective mechanism of HBO vasoconstriction.

Original languageRussian
Pages (from-to)553-559
Number of pages7
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume88
Issue number5
StatePublished - May 2002
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this