Hypertension and cerebrovascular disease

Askiel Bruno, L. S. Williams, J. Biller

Research output: Contribution to journalReview article

Abstract

Arterial hypertension plays a major part in stroke because it is a well-documented risk factor for stroke, it is common, and it can be treated effectively. Arterial hypertension leads to cerebrovascular disease through multiple mechanisms. Chronic hypertension accelerates cerebral vasculopathy in arteries of all sizes. These pathologic changes increase the risk of both ischemic and hemorrhagic stroke 2.7 times that in normotensive individuals. Hypertension also leads to ischemic heart disease, which in turn increases the risk of cardioembolic stroke. Effective treatment of chronic hypertension reduces the incidence of stroke 35% and has a large impact on health care statistics because of the prevalence of hypertension. Acute elevation of blood pressure above the level of cerebral blood flow autoregulation produces hypertensive encephalopathy. If recognized and treated promptly, the clinical and imaging abnormalities of hypertensive encephalopathy resolve within a few days. However, during acute ischemic stroke, endogenously elevated blood pressure may benefit the ischemic tissue, and lowering the blood pressure at this time seems to be detrimental.

Original languageEnglish (US)
Pages (from-to)314-323
Number of pages10
JournalCardiology in Review
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Cerebrovascular Disorders
Stroke
Hypertension
Hypertensive Encephalopathy
Blood Pressure
Cerebrovascular Circulation
Myocardial Ischemia
Homeostasis
Arteries
Delivery of Health Care
Incidence

Keywords

  • cerebral infarction
  • cerebrovascular disease
  • hypertension
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hypertension and cerebrovascular disease. / Bruno, Askiel; Williams, L. S.; Biller, J.

In: Cardiology in Review, Vol. 3, No. 6, 01.01.1995, p. 314-323.

Research output: Contribution to journalReview article

Bruno, Askiel ; Williams, L. S. ; Biller, J. / Hypertension and cerebrovascular disease. In: Cardiology in Review. 1995 ; Vol. 3, No. 6. pp. 314-323.
@article{3f495f113a6e41b4bb5fc318576d752c,
title = "Hypertension and cerebrovascular disease",
abstract = "Arterial hypertension plays a major part in stroke because it is a well-documented risk factor for stroke, it is common, and it can be treated effectively. Arterial hypertension leads to cerebrovascular disease through multiple mechanisms. Chronic hypertension accelerates cerebral vasculopathy in arteries of all sizes. These pathologic changes increase the risk of both ischemic and hemorrhagic stroke 2.7 times that in normotensive individuals. Hypertension also leads to ischemic heart disease, which in turn increases the risk of cardioembolic stroke. Effective treatment of chronic hypertension reduces the incidence of stroke 35{\%} and has a large impact on health care statistics because of the prevalence of hypertension. Acute elevation of blood pressure above the level of cerebral blood flow autoregulation produces hypertensive encephalopathy. If recognized and treated promptly, the clinical and imaging abnormalities of hypertensive encephalopathy resolve within a few days. However, during acute ischemic stroke, endogenously elevated blood pressure may benefit the ischemic tissue, and lowering the blood pressure at this time seems to be detrimental.",
keywords = "cerebral infarction, cerebrovascular disease, hypertension, stroke",
author = "Askiel Bruno and Williams, {L. S.} and J. Biller",
year = "1995",
month = "1",
day = "1",
doi = "10.1097/00045415-199511000-00004",
language = "English (US)",
volume = "3",
pages = "314--323",
journal = "Cardiology in Review",
issn = "1061-5377",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Hypertension and cerebrovascular disease

AU - Bruno, Askiel

AU - Williams, L. S.

AU - Biller, J.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Arterial hypertension plays a major part in stroke because it is a well-documented risk factor for stroke, it is common, and it can be treated effectively. Arterial hypertension leads to cerebrovascular disease through multiple mechanisms. Chronic hypertension accelerates cerebral vasculopathy in arteries of all sizes. These pathologic changes increase the risk of both ischemic and hemorrhagic stroke 2.7 times that in normotensive individuals. Hypertension also leads to ischemic heart disease, which in turn increases the risk of cardioembolic stroke. Effective treatment of chronic hypertension reduces the incidence of stroke 35% and has a large impact on health care statistics because of the prevalence of hypertension. Acute elevation of blood pressure above the level of cerebral blood flow autoregulation produces hypertensive encephalopathy. If recognized and treated promptly, the clinical and imaging abnormalities of hypertensive encephalopathy resolve within a few days. However, during acute ischemic stroke, endogenously elevated blood pressure may benefit the ischemic tissue, and lowering the blood pressure at this time seems to be detrimental.

AB - Arterial hypertension plays a major part in stroke because it is a well-documented risk factor for stroke, it is common, and it can be treated effectively. Arterial hypertension leads to cerebrovascular disease through multiple mechanisms. Chronic hypertension accelerates cerebral vasculopathy in arteries of all sizes. These pathologic changes increase the risk of both ischemic and hemorrhagic stroke 2.7 times that in normotensive individuals. Hypertension also leads to ischemic heart disease, which in turn increases the risk of cardioembolic stroke. Effective treatment of chronic hypertension reduces the incidence of stroke 35% and has a large impact on health care statistics because of the prevalence of hypertension. Acute elevation of blood pressure above the level of cerebral blood flow autoregulation produces hypertensive encephalopathy. If recognized and treated promptly, the clinical and imaging abnormalities of hypertensive encephalopathy resolve within a few days. However, during acute ischemic stroke, endogenously elevated blood pressure may benefit the ischemic tissue, and lowering the blood pressure at this time seems to be detrimental.

KW - cerebral infarction

KW - cerebrovascular disease

KW - hypertension

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=0028866288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028866288&partnerID=8YFLogxK

U2 - 10.1097/00045415-199511000-00004

DO - 10.1097/00045415-199511000-00004

M3 - Review article

VL - 3

SP - 314

EP - 323

JO - Cardiology in Review

JF - Cardiology in Review

SN - 1061-5377

IS - 6

ER -