TY - JOUR
T1 - Hypertension and immunity
T2 - Mechanisms of T cell activation and pathways of hypertension
AU - Abais-Battad, Justine M.
AU - Rudemiller, Nathan P.
AU - Mattson, David L.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Purpose of review The role of immune mechanisms to amplify hypertension in patients and animal models has been appreciated for decades. This review briefly summarizes recent studies exploring the mechanistic pathways, whereby the immune system participates in hypertension and renal disease. Recent findings Emphasis in this review is placed upon recent studies exploring the role of T cell subtypes, newly described mechanisms of T cell activation, the identification of potential neoantigens, and environmental influences on immune cell activation. Summary Significant advancements have been made in the search for antigens and pathways responsible for activation of the adaptive immune response, furthering our understanding of the factors contributing to hypertension and potentially leading to the development of new and more effective therapies.
AB - Purpose of review The role of immune mechanisms to amplify hypertension in patients and animal models has been appreciated for decades. This review briefly summarizes recent studies exploring the mechanistic pathways, whereby the immune system participates in hypertension and renal disease. Recent findings Emphasis in this review is placed upon recent studies exploring the role of T cell subtypes, newly described mechanisms of T cell activation, the identification of potential neoantigens, and environmental influences on immune cell activation. Summary Significant advancements have been made in the search for antigens and pathways responsible for activation of the adaptive immune response, furthering our understanding of the factors contributing to hypertension and potentially leading to the development of new and more effective therapies.
KW - Hypertension
KW - Immunity
KW - Renal disease
KW - T lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=84942587655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942587655&partnerID=8YFLogxK
U2 - 10.1097/MNH.0000000000000146
DO - 10.1097/MNH.0000000000000146
M3 - Review article
C2 - 26125645
AN - SCOPUS:84942587655
VL - 24
SP - 470
EP - 474
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
SN - 1062-4821
IS - 5
ER -