Hypertension and immunity: Mechanisms of T cell activation and pathways of hypertension

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Purpose of review The role of immune mechanisms to amplify hypertension in patients and animal models has been appreciated for decades. This review briefly summarizes recent studies exploring the mechanistic pathways, whereby the immune system participates in hypertension and renal disease. Recent findings Emphasis in this review is placed upon recent studies exploring the role of T cell subtypes, newly described mechanisms of T cell activation, the identification of potential neoantigens, and environmental influences on immune cell activation. Summary Significant advancements have been made in the search for antigens and pathways responsible for activation of the adaptive immune response, furthering our understanding of the factors contributing to hypertension and potentially leading to the development of new and more effective therapies.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalCurrent opinion in nephrology and hypertension
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Keywords

  • Hypertension
  • Immunity
  • Renal disease
  • T lymphocytes

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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