Hypertension in obese Zucker rats

Role of angiotensin II and adrenergic activity

Magdalena Alonso-Galicia, Michael W Brands, Dion H. Zappe, John E. Hall

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

We designed our studies to determine whether blood pressure is elevated in obese Zucker rats compared with lean control rats and to test the importance of the renin-angiotensin and adrenergic nervous systems in long- term blood pressure control in this genetic model of obesity. We monitored mean arterial pressure 24 hours per day using computerized methods in 13- to 14-week-old lean and obese Zucker rats maintained on a fixed, normal sodium intake (3.3 mmol/d). Mean arterial pressure (average of 5 days) was higher in obese (100±1 mm Hg) than in lean (86±1) rats. Although control plasma renin activity was lower in obese than in lean rats (3.66±0.15 versus 5.48±0.11 ng angiotensin l/mL per hour), blood pressure sensitivity to exogenous angiotensin II was greater in obese than in lean rats. Blockade of endogenous angiotensin II receptors with losartan (10 mg/kg per day) for 7 days also caused a greater decrease in blood pressure in obese (36±2 mm Hg, n=6) than in lean (25±1, n=5) rats. However, combined α- and β-adrenergic blockade with terazosin (10 mg/kg per day) and propranolol (10 mg/kg per day), respectively, for 8 days caused only modest decreases in blood pressure in obese (9±3 mm Hg, n=8) and lean (4±2, n=6) rats, despite effective α- and β-adrenergic blockade. These results suggest that increased arterial pressure in obese Zucker rats depends in part on angiotensin II. However, additional mechanisms may also contribute to increased blood pressure in obese Zucker rats.

Original languageEnglish (US)
Pages (from-to)1047-1054
Number of pages8
JournalHypertension
Volume28
Issue number6
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Fingerprint

Zucker Rats
Angiotensin II
Adrenergic Agents
Blood Pressure
Hypertension
Arterial Pressure
Terazosin
Angiotensins
Renin
Angiotensin Receptors
Losartan
Genetic Models
Propranolol
Nervous System
Obesity
Sodium

Keywords

  • blood pressure
  • kidney
  • obesity
  • renin
  • sodium
  • sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hypertension in obese Zucker rats : Role of angiotensin II and adrenergic activity. / Alonso-Galicia, Magdalena; Brands, Michael W; Zappe, Dion H.; Hall, John E.

In: Hypertension, Vol. 28, No. 6, 01.01.1996, p. 1047-1054.

Research output: Contribution to journalArticle

Alonso-Galicia, Magdalena ; Brands, Michael W ; Zappe, Dion H. ; Hall, John E. / Hypertension in obese Zucker rats : Role of angiotensin II and adrenergic activity. In: Hypertension. 1996 ; Vol. 28, No. 6. pp. 1047-1054.
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