Hypogonadotropic Hypogonadism

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Gonadotropin-releasing hormone (GnRH) and olfactory neurons migrate together from the olfactory placode, and GnRH neurons eventually reside in the hypothalamus. Hypogonadism in male infants may be diagnosed in the first 6 months of life but cannot be diagnosed during childhood until puberty occurs. Patients with low serum testosterone and low serum gonadotropin levels have idiopathic hypogonadotropic hypogonadism (IHH). Mutations in three genes (KAL1, FGFR1, and GNRHR) comprise most of the known genetic causes of IHH. Treatment with testosterone is indicated if fertility is not desired, whereas GnRH or gonadotropin treatment induces spermatogenesis and fertility.

Original languageEnglish (US)
Pages (from-to)283-296
Number of pages14
JournalEndocrinology and Metabolism Clinics of North America
Volume36
Issue number2
DOIs
StatePublished - Jun 1 2007

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Hypogonadism
Gonadotropin-Releasing Hormone
Gonadotropins
Neurons
Fertility
Testosterone
Eunuchism
Spermatogenesis
Puberty
Serum
Hypothalamus
Genes
Mutation
Therapeutics
Idiopathic Hypogonadotropic Hypogonadism

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry

Cite this

Hypogonadotropic Hypogonadism. / Layman, Lawrence C.

In: Endocrinology and Metabolism Clinics of North America, Vol. 36, No. 2, 01.06.2007, p. 283-296.

Research output: Contribution to journalReview article

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