Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure

Shadwan Alsafwah, Stephen P. Laguardia, Maeda D. Nelson, David L. Battin, Kevin P. Newman, Laura D Carbone, Karl T. Weber

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Factors contributing to heart failure (HF) in African Americans (AA) are under investigation. Reduced 25(OH)D confers increased cardiovascular risk, including HF. METHODS: We monitored serum 25(OH)D, 1,25(OH)2D3, parathyroid hormone (PTH), and creatinine clearance in 102 AA residing in Memphis: 58 hospitalized with decompensated HF of ≥4 weeks in 34 (21 men; 53.3 ± 1.8 years) or of 1 to 2 weeks in 24 (17 men; 49.6 ± 2.4 years) and associated with a dilated cardiomyopathy and reduced ejection fraction (<35%); 19 outpatients with compensated HF (14 men; 52.6 ± 2.7 years) with comparable ejection fraction; 16 outpatients (9 men; 55.4 ± 2.9 years) with heart disease, but without HF; and 9 healthy volunteers (3 men; 35.8 ± 3.5 years). RESULTS: Serum 25(OH)D ≤30 ng/mL was found in 96% and 90% with protracted or short-term decompensated HF, where it was of moderate to marked severity (<20 ng/mL) in 83% and 76%, respectively. In patients with either compensated or no HF, 25(OH)D <30 ng/mL was found in 95% and 100%, respectively, and in 30% of volunteers. Normal serum 1,25(OH)2D3 did not differ between patients. Serum PTH >65 pg/mL was found in all AA with decompensated HF of ≥4 weeks (132.4 ± 12.0 pg/mL) and 67% with 1 to 2 weeks duration (82.3 ± 7.9 pg/mL), but only 11% with compensated HF (45.8 ± 6.1 pg/mL), 12% without HF (29.6 ± 5.4 pg/mL), and none of the volunteers (31.1 ± 3.9 pg/mL). Creatinine clearance did not differ between patient groups. CONCLUSIONS: Hypovitaminosis D is prevalent amongst AA residing in Memphis, with or without HF. Elevations in serum PTH in keeping with secondary hyperparathyroidism are only found in AA with decompensated HF, where hypovitaminosis D and other factors are contributory.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume335
Issue number4
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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African Americans
Heart Failure
Parathyroid Hormone
Creatinine
Secondary Hyperparathyroidism
Dilated Cardiomyopathy
Serum
Volunteers

Keywords

  • African Americans
  • Heart failure
  • Hypovitaminosis D
  • Secondary hyperparathyroidism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure. / Alsafwah, Shadwan; Laguardia, Stephen P.; Nelson, Maeda D.; Battin, David L.; Newman, Kevin P.; Carbone, Laura D; Weber, Karl T.

In: American Journal of the Medical Sciences, Vol. 335, No. 4, 01.01.2008, p. 292-297.

Research output: Contribution to journalArticle

Alsafwah, Shadwan ; Laguardia, Stephen P. ; Nelson, Maeda D. ; Battin, David L. ; Newman, Kevin P. ; Carbone, Laura D ; Weber, Karl T. / Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure. In: American Journal of the Medical Sciences. 2008 ; Vol. 335, No. 4. pp. 292-297.
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abstract = "BACKGROUND: Factors contributing to heart failure (HF) in African Americans (AA) are under investigation. Reduced 25(OH)D confers increased cardiovascular risk, including HF. METHODS: We monitored serum 25(OH)D, 1,25(OH)2D3, parathyroid hormone (PTH), and creatinine clearance in 102 AA residing in Memphis: 58 hospitalized with decompensated HF of ≥4 weeks in 34 (21 men; 53.3 ± 1.8 years) or of 1 to 2 weeks in 24 (17 men; 49.6 ± 2.4 years) and associated with a dilated cardiomyopathy and reduced ejection fraction (<35{\%}); 19 outpatients with compensated HF (14 men; 52.6 ± 2.7 years) with comparable ejection fraction; 16 outpatients (9 men; 55.4 ± 2.9 years) with heart disease, but without HF; and 9 healthy volunteers (3 men; 35.8 ± 3.5 years). RESULTS: Serum 25(OH)D ≤30 ng/mL was found in 96{\%} and 90{\%} with protracted or short-term decompensated HF, where it was of moderate to marked severity (<20 ng/mL) in 83{\%} and 76{\%}, respectively. In patients with either compensated or no HF, 25(OH)D <30 ng/mL was found in 95{\%} and 100{\%}, respectively, and in 30{\%} of volunteers. Normal serum 1,25(OH)2D3 did not differ between patients. Serum PTH >65 pg/mL was found in all AA with decompensated HF of ≥4 weeks (132.4 ± 12.0 pg/mL) and 67{\%} with 1 to 2 weeks duration (82.3 ± 7.9 pg/mL), but only 11{\%} with compensated HF (45.8 ± 6.1 pg/mL), 12{\%} without HF (29.6 ± 5.4 pg/mL), and none of the volunteers (31.1 ± 3.9 pg/mL). Creatinine clearance did not differ between patient groups. CONCLUSIONS: Hypovitaminosis D is prevalent amongst AA residing in Memphis, with or without HF. Elevations in serum PTH in keeping with secondary hyperparathyroidism are only found in AA with decompensated HF, where hypovitaminosis D and other factors are contributory.",
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AU - Laguardia, Stephen P.

AU - Nelson, Maeda D.

AU - Battin, David L.

AU - Newman, Kevin P.

AU - Carbone, Laura D

AU - Weber, Karl T.

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N2 - BACKGROUND: Factors contributing to heart failure (HF) in African Americans (AA) are under investigation. Reduced 25(OH)D confers increased cardiovascular risk, including HF. METHODS: We monitored serum 25(OH)D, 1,25(OH)2D3, parathyroid hormone (PTH), and creatinine clearance in 102 AA residing in Memphis: 58 hospitalized with decompensated HF of ≥4 weeks in 34 (21 men; 53.3 ± 1.8 years) or of 1 to 2 weeks in 24 (17 men; 49.6 ± 2.4 years) and associated with a dilated cardiomyopathy and reduced ejection fraction (<35%); 19 outpatients with compensated HF (14 men; 52.6 ± 2.7 years) with comparable ejection fraction; 16 outpatients (9 men; 55.4 ± 2.9 years) with heart disease, but without HF; and 9 healthy volunteers (3 men; 35.8 ± 3.5 years). RESULTS: Serum 25(OH)D ≤30 ng/mL was found in 96% and 90% with protracted or short-term decompensated HF, where it was of moderate to marked severity (<20 ng/mL) in 83% and 76%, respectively. In patients with either compensated or no HF, 25(OH)D <30 ng/mL was found in 95% and 100%, respectively, and in 30% of volunteers. Normal serum 1,25(OH)2D3 did not differ between patients. Serum PTH >65 pg/mL was found in all AA with decompensated HF of ≥4 weeks (132.4 ± 12.0 pg/mL) and 67% with 1 to 2 weeks duration (82.3 ± 7.9 pg/mL), but only 11% with compensated HF (45.8 ± 6.1 pg/mL), 12% without HF (29.6 ± 5.4 pg/mL), and none of the volunteers (31.1 ± 3.9 pg/mL). Creatinine clearance did not differ between patient groups. CONCLUSIONS: Hypovitaminosis D is prevalent amongst AA residing in Memphis, with or without HF. Elevations in serum PTH in keeping with secondary hyperparathyroidism are only found in AA with decompensated HF, where hypovitaminosis D and other factors are contributory.

AB - BACKGROUND: Factors contributing to heart failure (HF) in African Americans (AA) are under investigation. Reduced 25(OH)D confers increased cardiovascular risk, including HF. METHODS: We monitored serum 25(OH)D, 1,25(OH)2D3, parathyroid hormone (PTH), and creatinine clearance in 102 AA residing in Memphis: 58 hospitalized with decompensated HF of ≥4 weeks in 34 (21 men; 53.3 ± 1.8 years) or of 1 to 2 weeks in 24 (17 men; 49.6 ± 2.4 years) and associated with a dilated cardiomyopathy and reduced ejection fraction (<35%); 19 outpatients with compensated HF (14 men; 52.6 ± 2.7 years) with comparable ejection fraction; 16 outpatients (9 men; 55.4 ± 2.9 years) with heart disease, but without HF; and 9 healthy volunteers (3 men; 35.8 ± 3.5 years). RESULTS: Serum 25(OH)D ≤30 ng/mL was found in 96% and 90% with protracted or short-term decompensated HF, where it was of moderate to marked severity (<20 ng/mL) in 83% and 76%, respectively. In patients with either compensated or no HF, 25(OH)D <30 ng/mL was found in 95% and 100%, respectively, and in 30% of volunteers. Normal serum 1,25(OH)2D3 did not differ between patients. Serum PTH >65 pg/mL was found in all AA with decompensated HF of ≥4 weeks (132.4 ± 12.0 pg/mL) and 67% with 1 to 2 weeks duration (82.3 ± 7.9 pg/mL), but only 11% with compensated HF (45.8 ± 6.1 pg/mL), 12% without HF (29.6 ± 5.4 pg/mL), and none of the volunteers (31.1 ± 3.9 pg/mL). Creatinine clearance did not differ between patient groups. CONCLUSIONS: Hypovitaminosis D is prevalent amongst AA residing in Memphis, with or without HF. Elevations in serum PTH in keeping with secondary hyperparathyroidism are only found in AA with decompensated HF, where hypovitaminosis D and other factors are contributory.

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