Hypoxia, HIF, and associated signaling networks in chronic kidney disease

Jing Liu, Qingqing Wei, Chunyuan Guo, Guie Dong, Yu Liu, Chengyuan Tang, Zheng Dong

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial. Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD. Hypoxia inducible factors (HIF) are a small family of transcription factors that are mainly responsive to hypoxia and mediate hypoxic response. HIF plays a critical role in renal fibrosis during CKD through the modulation of gene transcription, crosstalk with multiple signaling pathways, epithelial-mesenchymal transition, and epigenetic regulation. Moreover, HIF also contributes to the development of various pathological conditions associated with CKD, such as anemia, inflammation, aberrant angiogenesis, and vascular calcification. Treatments targeting HIF and related signaling pathways for CKD therapy are being developed with promising clinical benefits, especially for anemia. This review presents an updated analysis of hypoxia response, HIF, and their associated signaling network involved in the pathogenesis of CKD.

Original languageEnglish (US)
Article number950
JournalInternational journal of molecular sciences
Volume18
Issue number5
DOIs
StatePublished - May 2017

Fingerprint

kidney diseases
hypoxia
Chronic Renal Insufficiency
anemias
pathogenesis
Oxygen supply
Anemia
Transcription factors
Transcription
Crosstalk
Vascular Calcification
Kidney
angiogenesis
calcification
fibrosis
Epithelial-Mesenchymal Transition
Hypoxia
kidneys
Transcription Factors
Genes

Keywords

  • CKD
  • Fibrosis
  • HIF
  • Hypoxia

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Hypoxia, HIF, and associated signaling networks in chronic kidney disease. / Liu, Jing; Wei, Qingqing; Guo, Chunyuan; Dong, Guie; Liu, Yu; Tang, Chengyuan; Dong, Zheng.

In: International journal of molecular sciences, Vol. 18, No. 5, 950, 05.2017.

Research output: Contribution to journalReview article

Liu, Jing ; Wei, Qingqing ; Guo, Chunyuan ; Dong, Guie ; Liu, Yu ; Tang, Chengyuan ; Dong, Zheng. / Hypoxia, HIF, and associated signaling networks in chronic kidney disease. In: International journal of molecular sciences. 2017 ; Vol. 18, No. 5.
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