Id transcriptional regulators in adipogenesis and adipose tissue metabolism

Mallikarjun Patil, Bal Krishan Sharma, Satyanarayana Ande

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helixloop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins are implicated in the regulation of various cellular mechanisms such as cell proliferation, cellular differentiation, cell fate determination, angiogenesis and tumorigenesis. A handful of recent studies also disclosed that Id proteins have critical functions in adipocyte differentiation and adipose tissue metabolism. Here, we reviewed the progress made thus far in understanding the specific functions of Id proteins in adipose tissue differentiation and metabolism. In addition to reviewing the known mechanisms of action, we also discuss possible additional mechanisms in which Id proteins might participate in regulating adipogenic and metabolic pathways.

Original languageEnglish (US)
Pages (from-to)1386-1397
Number of pages12
JournalFrontiers in Bioscience - Landmark
Volume19
Issue number8
DOIs
Publication statusPublished - Jun 1 2014

    Fingerprint

Keywords

  • BAT
  • Insulin sensitivity
  • Lipid metabolism
  • Review
  • Thermogenesis
  • WAT

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this