Identification of a large pool of microorganisms with an array of porphyrin based gas sensors

Nicola M. Zetola; Chawangwa Modongo; Keikantse Mathlagela; Enoch Sepako; Ogopotse Matsiri; Tsaone Tamuhla; Bontle Mbongwe; Eugenio Martinelli; Giorgio Sirugo; Roberto Paolesse; Corrado Di Natale

doi:10.3390/s16040466

Identification of a large pool of microorganisms with an array of porphyrin based gas sensors

Nicola M. Zetola, Chawangwa Modongo, Keikantse Mathlagela, Enoch Sepako, Ogopotse Matsiri, Tsaone Tamuhla, Bontle Mbongwe, Eugenio Martinelli, Giorgio Sirugo, Roberto Paolesse, Corrado Di Natale

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The association between volatile compounds (VCs) and microorganisms, as demonstrated by several studies, may offer the ground for a rapid identification of pathogens. To this regard, chemical sensors are a key enabling technology for the exploitation of this opportunity. In this study, we investigated the performance of an array of porphyrin-coated quartz microbalance gas sensors in the identification of a panel of 12 bacteria and fungi. The porphyrins were metal complexes and the free base of a functionalized tetraphenylporphyrin. Our results show that the sensor array distinguishes the VC patterns produced by microorganisms in vitro. Besides being individually identified, bacteria are also sorted into Gram-positive and Gram-negative.

Original language	English (US)
Article number	466
Journal	Sensors
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/s16040466
State	Published - Apr 1 2016
Externally published	Yes

Keywords

Microorganisms
Porphyrins
Quartz microbalance
Volatile compounds

ASJC Scopus subject areas

Analytical Chemistry
Information Systems
Atomic and Molecular Physics, and Optics
Biochemistry
Instrumentation
Electrical and Electronic Engineering

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10.3390/s16040466

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abstract = "The association between volatile compounds (VCs) and microorganisms, as demonstrated by several studies, may offer the ground for a rapid identification of pathogens. To this regard, chemical sensors are a key enabling technology for the exploitation of this opportunity. In this study, we investigated the performance of an array of porphyrin-coated quartz microbalance gas sensors in the identification of a panel of 12 bacteria and fungi. The porphyrins were metal complexes and the free base of a functionalized tetraphenylporphyrin. Our results show that the sensor array distinguishes the VC patterns produced by microorganisms in vitro. Besides being individually identified, bacteria are also sorted into Gram-positive and Gram-negative.",

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AU - Zetola, Nicola M.

AU - Modongo, Chawangwa

AU - Mathlagela, Keikantse

AU - Sepako, Enoch

AU - Matsiri, Ogopotse

AU - Tamuhla, Tsaone

AU - Mbongwe, Bontle

AU - Martinelli, Eugenio

AU - Sirugo, Giorgio

AU - Paolesse, Roberto

AU - Di Natale, Corrado

PY - 2016/4/1

Y1 - 2016/4/1

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AB - The association between volatile compounds (VCs) and microorganisms, as demonstrated by several studies, may offer the ground for a rapid identification of pathogens. To this regard, chemical sensors are a key enabling technology for the exploitation of this opportunity. In this study, we investigated the performance of an array of porphyrin-coated quartz microbalance gas sensors in the identification of a panel of 12 bacteria and fungi. The porphyrins were metal complexes and the free base of a functionalized tetraphenylporphyrin. Our results show that the sensor array distinguishes the VC patterns produced by microorganisms in vitro. Besides being individually identified, bacteria are also sorted into Gram-positive and Gram-negative.

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KW - Porphyrins

KW - Quartz microbalance

KW - Volatile compounds

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Identification of a large pool of microorganisms with an array of porphyrin based gas sensors

Abstract

Keywords

ASJC Scopus subject areas

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