Abstract
Purpose: To determine common molecular markers between endometriosis and ovarian cancer. Methods: Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions (n=7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum (n=7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR. Results: Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR. Conclusions: Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases.
Original language | English (US) |
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Pages (from-to) | 917-923 |
Number of pages | 7 |
Journal | Journal of Assisted Reproduction and Genetics |
Volume | 28 |
Issue number | 10 |
DOIs | |
State | Published - Sep 2011 |
Externally published | Yes |
Keywords
- Aromatase
- COX-2
- Endometriosis
- Hormone receptors
- Ovarian cancer
- TGF-β1
- VEGF
ASJC Scopus subject areas
- Reproductive Medicine
- Genetics
- Obstetrics and Gynecology
- Developmental Biology
- Genetics(clinical)