Identification of common mechanisms between endometriosis and ovarian cancer

Qingsong Meng, Weixue Sun, John Jiang, Nicole M. Fletcher, Michael P. Diamond, Ghassan M. Saed

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Purpose: To determine common molecular markers between endometriosis and ovarian cancer. Methods: Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions (n=7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum (n=7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR. Results: Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR. Conclusions: Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases.

Original languageEnglish (US)
Pages (from-to)917-923
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume28
Issue number10
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Keywords

  • Aromatase
  • COX-2
  • Endometriosis
  • Hormone receptors
  • Ovarian cancer
  • TGF-β1
  • VEGF

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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