Identification of Emergency Department Patients With Acute Heart Failure at Low Risk for 30-Day Adverse Events

The STRATIFY Decision Tool

Sean P. Collins, Cathy A. Jenkins, Frank E. Harrell, Dandan Liu, Karen F. Miller, Christopher J. Lindsell, Allen J. Naftilan, John A. McPherson, David J. Maron, Douglas B. Sawyer, Neal Lee Weintraub, Gregory J. Fermann, Susan K. Roll, Matthew Sperling, Alan B. Storrow

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objectives: No prospectively derived or validated decision tools identify emergency department (ED) patients with acute heart failure (AHF) at low risk for 30-day adverse events who are thus potential candidates for safe ED discharge. This study sought to accomplish that goal. Background: The nearly 1 million annual ED visits for AHF are associated with high proportions of admissions and consume significant resources. Methods: We prospectively enrolled 1,033 patients diagnosed with AHF in the ED from 4 hospitals between July 20, 2007, and February 4, 2011. We used an ordinal outcome hierarchy, defined as the incidence of the most severe adverse event within 30 days of ED evaluation (acute coronary syndrome, coronary revascularization, emergent dialysis, intubation, mechanical cardiac support, cardiopulmonary resuscitation, and death). Results: Of 1,033 patients enrolled, 126 (12%) experienced at least one 30-day adverse event. The decision tool had a C statistic of 0.68 (95% confidence interval: 0.63 to 0.74). Elevated troponin (p < 0.001) and renal function (p = 0.01) were significant predictors of adverse events in our multivariable model, whereas B-type natriuretic peptide (p = 0.09), tachypnea (p = 0.09), and patients undergoing dialysis (p = 0.07) trended toward significance. At risk thresholds of 1%, 3%, and 5%, we found 0%, 1.4%, and 13.0% patients were at low risk, with negative predictive values of 100%, 96%, and 93%, respectively. Conclusions: The STRATIFY decision tool identifies ED patients with AHF who are at low risk for 30-day adverse events and may be candidates for safe ED discharge. After external testing, and perhaps when used as part of a shared decision-making strategy, it may significantly affect disposition strategies. (Improving Heart Failure Risk Stratification in the ED [STRATIFY]; NCT00508638).

Original languageEnglish (US)
Article number338
Pages (from-to)737-747
Number of pages11
JournalJACC: Heart Failure
Volume3
Issue number10
DOIs
StatePublished - Oct 1 2015

Fingerprint

Hospital Emergency Service
Heart Failure
Dialysis
Tachypnea
Troponin
Brain Natriuretic Peptide
Cardiopulmonary Resuscitation
Acute Coronary Syndrome
Intubation
Decision Making
Confidence Intervals
Kidney
Incidence

Keywords

  • Acute heart failure
  • Decision tool
  • Emergency department
  • Prospective study

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Collins, S. P., Jenkins, C. A., Harrell, F. E., Liu, D., Miller, K. F., Lindsell, C. J., ... Storrow, A. B. (2015). Identification of Emergency Department Patients With Acute Heart Failure at Low Risk for 30-Day Adverse Events: The STRATIFY Decision Tool. JACC: Heart Failure, 3(10), 737-747. [338]. https://doi.org/10.1016/j.jchf.2015.05.007

Identification of Emergency Department Patients With Acute Heart Failure at Low Risk for 30-Day Adverse Events : The STRATIFY Decision Tool. / Collins, Sean P.; Jenkins, Cathy A.; Harrell, Frank E.; Liu, Dandan; Miller, Karen F.; Lindsell, Christopher J.; Naftilan, Allen J.; McPherson, John A.; Maron, David J.; Sawyer, Douglas B.; Weintraub, Neal Lee; Fermann, Gregory J.; Roll, Susan K.; Sperling, Matthew; Storrow, Alan B.

In: JACC: Heart Failure, Vol. 3, No. 10, 338, 01.10.2015, p. 737-747.

Research output: Contribution to journalArticle

Collins, SP, Jenkins, CA, Harrell, FE, Liu, D, Miller, KF, Lindsell, CJ, Naftilan, AJ, McPherson, JA, Maron, DJ, Sawyer, DB, Weintraub, NL, Fermann, GJ, Roll, SK, Sperling, M & Storrow, AB 2015, 'Identification of Emergency Department Patients With Acute Heart Failure at Low Risk for 30-Day Adverse Events: The STRATIFY Decision Tool', JACC: Heart Failure, vol. 3, no. 10, 338, pp. 737-747. https://doi.org/10.1016/j.jchf.2015.05.007
Collins, Sean P. ; Jenkins, Cathy A. ; Harrell, Frank E. ; Liu, Dandan ; Miller, Karen F. ; Lindsell, Christopher J. ; Naftilan, Allen J. ; McPherson, John A. ; Maron, David J. ; Sawyer, Douglas B. ; Weintraub, Neal Lee ; Fermann, Gregory J. ; Roll, Susan K. ; Sperling, Matthew ; Storrow, Alan B. / Identification of Emergency Department Patients With Acute Heart Failure at Low Risk for 30-Day Adverse Events : The STRATIFY Decision Tool. In: JACC: Heart Failure. 2015 ; Vol. 3, No. 10. pp. 737-747.
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AU - Harrell, Frank E.

AU - Liu, Dandan

AU - Miller, Karen F.

AU - Lindsell, Christopher J.

AU - Naftilan, Allen J.

AU - McPherson, John A.

AU - Maron, David J.

AU - Sawyer, Douglas B.

AU - Weintraub, Neal Lee

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KW - Acute heart failure

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