Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies

Hirokazu Yamaguchi, James R. Goldenring, Michio Kaminishi, Jeffrey R. Lee

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Following gastrectomy, the remnant oxyntic mucosa is at increased risk of developing adenocarcinoma. Alkaline pancreaticoduodenal reflux, carcinogen production from intragastric bacterial overgrowth, denervation, and devascularization have been implicated in this malignant transformation. Recent reports have described a novel spasmolytic polypeptide (SP) expressing metaplastic lineage designated as SPEM. This lineage has been identified in the mucosa surrounding gastric adenocarcinomas, and SP staining has been observed in the cells of surface dysplasia and invasive malignancy. In this study we describe 19 cases of remnant gastric adenocarcinoma from Japan. In addition, we studied surveillance biopsies in 90 patients who underwent antrectomy for carcinoma. SPEM was identified in the mucosa surrounding 88% of the remnant cancers, as well as in 61% of the surveillance biopsies. In the malignant resections, 67% of the surface dysplasia displayed SP positive cells, and 25% revealed SP immunostaining within invasive malignant cells. These findings implicate SPEM as a potential precursor lesion of gastric adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)573-578
Number of pages6
JournalDigestive Diseases and Sciences
Volume47
Issue number3
DOIs
StatePublished - Mar 23 2002

Fingerprint

Gastric Stump
Metaplasia
Stomach Neoplasms
Biopsy
Adenocarcinoma
Mucous Membrane
Denervation
Gastrectomy
Gastric Mucosa
spasmolytic polypeptide
Carcinogens
Neoplasms
Stomach
Japan
Staining and Labeling
Carcinoma

Keywords

  • Intestinal metaplasia
  • Remnant adenocarcinoma
  • SPEM
  • Spasmolytic polypeptide

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. / Yamaguchi, Hirokazu; Goldenring, James R.; Kaminishi, Michio; Lee, Jeffrey R.

In: Digestive Diseases and Sciences, Vol. 47, No. 3, 23.03.2002, p. 573-578.

Research output: Contribution to journalArticle

Yamaguchi, Hirokazu ; Goldenring, James R. ; Kaminishi, Michio ; Lee, Jeffrey R. / Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. In: Digestive Diseases and Sciences. 2002 ; Vol. 47, No. 3. pp. 573-578.
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