Identification of the molecular genetic defect of patients with methemoglobin M Kankakee (M-Iwate), α87 (F8) His → Tyr: Evidence for an electrostatic model of αM hemoglobin assembly

A. Ameri, V. F. Fairbanks, G. A. Yanik, F. Mahdi, S. N. Thibodeau, D. J. McCormick, L. A. Boxer, K. T. McDonagh

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, α87 (F8) His → Tyr] resides in the α1-globin gene. The proportion of Hb M observed is higher than that predicted for an α1-globin variant. Our evidence suggests that the greater-than-expected proportion of Hb M-Kankakee results from preferential association of the electronegative β-globin chains with the α(M)-globin chains that are more electropositive than normal α-globin chains.

Original languageEnglish (US)
Pages (from-to)1825-1826
Number of pages2
JournalBlood
Volume94
Issue number5
DOIs
StatePublished - Sep 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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