Idiopathic IgA nephropathy: Pathogenesis, histopathology, and therapeutic options

James A. Tumlin, Michael P. Madaio, Randolph Hennigar

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

IgA nephropathy is one of the most common causes of glomerulonephritis in the world. Proliferative and crescentic forms of IgA are found in up to 30% of cases and are associated with nephrotic-range proteinuria, accelerated hypertension, and accelerated decline toward ESRD. Despite its prevalence and clinical importance, there is no unifying nomenclature or consensus for the treatment of specific histologic subgroups. As a consequence, the development of clinically effective treatment regimens for IgA nephropathy have lagged behind other, less common forms of glomerulonephritis. Herein is reviewed the pathogenesis and histologic subtypes of IgA nephropathy and how conventional and immunosuppressive therapies have an impact on renal survival and recurrence rates. The use of known clinical risk factors for disease progression in conjunction with specific histologic features can be a guide to both induction and consolidation therapies for individual patients with IgA nephropathy.

Original languageEnglish (US)
Pages (from-to)1054-1061
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume2
Issue number5
DOIs
StatePublished - Sep 1 2007

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Immunoglobulin A
Glomerulonephritis
Therapeutics
Immunosuppressive Agents
Proteinuria
Terminology
Chronic Kidney Failure
Disease Progression
Survival Rate
Hypertension
Kidney
Recurrence

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Idiopathic IgA nephropathy : Pathogenesis, histopathology, and therapeutic options. / Tumlin, James A.; Madaio, Michael P.; Hennigar, Randolph.

In: Clinical Journal of the American Society of Nephrology, Vol. 2, No. 5, 01.09.2007, p. 1054-1061.

Research output: Contribution to journalReview article

Tumlin, James A. ; Madaio, Michael P. ; Hennigar, Randolph. / Idiopathic IgA nephropathy : Pathogenesis, histopathology, and therapeutic options. In: Clinical Journal of the American Society of Nephrology. 2007 ; Vol. 2, No. 5. pp. 1054-1061.
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