IDO and tolerance to tumors

David H. Munn, Andrew L. Mellor

Research output: Contribution to journalArticle

208 Scopus citations

Abstract

Tumors create a pathological state of tolerance towards tumor-associated antigens. The mechanisms by which this occurs are still largely unknown. Recent studies suggest that one mechanism contributing to this phenomenon could be tryptophan catabolism carried out by the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). IDO can be expressed by tumor cells themselves, and we propose that the recruitment of antigen-presenting cells expressing IDO to tumor-draining lymph nodes might constitute another potent mechanism for inducing tolerance to tumor-derived antigens. Therapeutic strategies based on blocking this pathway might represent a novel class of adjuvants for tumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalTrends in Molecular Medicine
Volume10
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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