IDO expression by dendritic cells: Tolerance and tryptophan catabolism

Andrew L. Mellor, David H. Munn

Research output: Contribution to journalReview article

1622 Scopus citations

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.

Original languageEnglish (US)
Pages (from-to)762-774
Number of pages13
JournalNature Reviews Immunology
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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