IDO expression by dendritic cells: Tolerance and tryptophan catabolism

Andrew L. Mellor, David H. Munn

Research output: Contribution to journalReview article

1558 Citations (Scopus)

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.

Original languageEnglish (US)
Pages (from-to)762-774
Number of pages13
JournalNature Reviews Immunology
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2004

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Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan
Dendritic Cells
Essential Amino Acids
Allergy and Immunology
Autoimmune Diseases
Chronic Disease
T-Lymphocytes
Pregnancy
Enzymes
Infection
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

IDO expression by dendritic cells : Tolerance and tryptophan catabolism. / Mellor, Andrew L.; Munn, David H.

In: Nature Reviews Immunology, Vol. 4, No. 10, 01.10.2004, p. 762-774.

Research output: Contribution to journalReview article

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