IDO in Human Gut Graft-versus-Host Disease

Philippe Ratajczak, Anne Janin, Régis Peffault de Larour, Lisa Koch, Brigitte Roche, David H Munn, Bruce R. Blazar, Gérard Socié

Research output: Contribution to journalArticle

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Abstract

Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO + cells were a novel population of CD3 +CD4 +IDO + cells. The proportion of CD4 +IDO + T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.

Original languageEnglish (US)
Pages (from-to)150-155
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Indoleamine-Pyrrole 2,3,-Dioxygenase
Graft vs Host Disease
Regulatory T-Lymphocytes
Dendritic Cells
Rodentia
Coloring Agents
Cell Count
Epithelial Cells
Macrophages
T-Lymphocytes
Biopsy

Keywords

  • Graft-vs-host disease
  • IDO
  • Regulatory T cells
  • Th17

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Ratajczak, P., Janin, A., Peffault de Larour, R., Koch, L., Roche, B., Munn, D. H., ... Socié, G. (2012). IDO in Human Gut Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation, 18(1), 150-155. https://doi.org/10.1016/j.bbmt.2011.08.002

IDO in Human Gut Graft-versus-Host Disease. / Ratajczak, Philippe; Janin, Anne; Peffault de Larour, Régis; Koch, Lisa; Roche, Brigitte; Munn, David H; Blazar, Bruce R.; Socié, Gérard.

In: Biology of Blood and Marrow Transplantation, Vol. 18, No. 1, 01.01.2012, p. 150-155.

Research output: Contribution to journalArticle

Ratajczak, P, Janin, A, Peffault de Larour, R, Koch, L, Roche, B, Munn, DH, Blazar, BR & Socié, G 2012, 'IDO in Human Gut Graft-versus-Host Disease', Biology of Blood and Marrow Transplantation, vol. 18, no. 1, pp. 150-155. https://doi.org/10.1016/j.bbmt.2011.08.002
Ratajczak P, Janin A, Peffault de Larour R, Koch L, Roche B, Munn DH et al. IDO in Human Gut Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation. 2012 Jan 1;18(1):150-155. https://doi.org/10.1016/j.bbmt.2011.08.002
Ratajczak, Philippe ; Janin, Anne ; Peffault de Larour, Régis ; Koch, Lisa ; Roche, Brigitte ; Munn, David H ; Blazar, Bruce R. ; Socié, Gérard. / IDO in Human Gut Graft-versus-Host Disease. In: Biology of Blood and Marrow Transplantation. 2012 ; Vol. 18, No. 1. pp. 150-155.
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