IDO in Human Gut Graft-versus-Host Disease

Philippe Ratajczak; Anne Janin; Régis Peffault de Larour; Lisa Koch; Brigitte Roche; David Munn; Bruce R. Blazar; Gérard Socié

doi:10.1016/j.bbmt.2011.08.002

IDO in Human Gut Graft-versus-Host Disease

Philippe Ratajczak, Anne Janin, Régis Peffault de Larour, Lisa Koch, Brigitte Roche, David Munn, Bruce R. Blazar, Gérard Socié

Pediatric Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO ⁺ cells were a novel population of CD3 ⁺CD4 ⁺IDO ⁺ cells. The proportion of CD4 ⁺IDO ⁺ T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.

Original language	English (US)
Pages (from-to)	150-155
Number of pages	6
Journal	Biology of Blood and Marrow Transplantation
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.bbmt.2011.08.002
State	Published - Jan 2012

Keywords

Graft-vs-host disease
IDO
Regulatory T cells
Th17

ASJC Scopus subject areas

Hematology
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbmt.2011.08.002

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title = "IDO in Human Gut Graft-versus-Host Disease",

abstract = "Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO + cells were a novel population of CD3 +CD4 +IDO + cells. The proportion of CD4 +IDO + T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.",

keywords = "Graft-vs-host disease, IDO, Regulatory T cells, Th17",

author = "Philippe Ratajczak and Anne Janin and {Peffault de Larour}, R{\'e}gis and Lisa Koch and Brigitte Roche and David Munn and Blazar, {Bruce R.} and G{\'e}rard Soci{\'e}",

note = "Funding Information: Financial disclosure: This research was supported by a grant from the European Commission StemDiagnositics Contract No. LSHB-CT-2007-037703 , and by Institut National du Cancer and Canc{\'e}rop{\^o}le Ile de France, Conseil r{\'e}gional Ile de France, Agence de Biom{\'e}decine, and NIH Grants R01 AI34495, R01 CA 72 669, and R37 HL56067 . ",

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AU - Ratajczak, Philippe

AU - Janin, Anne

AU - Peffault de Larour, Régis

AU - Koch, Lisa

AU - Roche, Brigitte

AU - Munn, David

AU - Blazar, Bruce R.

AU - Socié, Gérard

N1 - Funding Information: Financial disclosure: This research was supported by a grant from the European Commission StemDiagnositics Contract No. LSHB-CT-2007-037703 , and by Institut National du Cancer and Cancéropôle Ile de France, Conseil régional Ile de France, Agence de Biomédecine, and NIH Grants R01 AI34495, R01 CA 72 669, and R37 HL56067 .

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N2 - Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO + cells were a novel population of CD3 +CD4 +IDO + cells. The proportion of CD4 +IDO + T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.

AB - Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO + cells were a novel population of CD3 +CD4 +IDO + cells. The proportion of CD4 +IDO + T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.

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IDO in Human Gut Graft-versus-Host Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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