Ige and cardiovascular disease. Results from a population-based study

Michael H. Criqui, Edwin R. Lee, Robert N. Hamburger, Melville R. Klauber, Steven Scott Coughlin

Research output: Contribution to journalArticle

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Abstract

Because previous reports have suggested that IgE-mediated events may lead to both platelet activation and arterial spasm, a population-based study of 262 men and 315 women, aged 38 to 82, was conducted to investigate the association of serum IgE levels with myocardial infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial disease. In men with previous myocardial infarction, previous stroke, or current large-vessel peripheral arterial disease, geometric mean serum IgE levels were increased 119 percent, 164 percent, and 78 percent, respectively. These associations were statistically significant (p <0.05). Because IgE was positively or inversely correlated with several traditional cardiovascular disease risk factors, logistic regression was used to evaluate the independent association of IgE with any cardiovascular disease (myocardial infarction, stroke, or large-vessel peripheral arterial disease). In a model including age, cigarette smoking, fasting plasma glucose level, diastolic blood pressure, and low-density lipoprotein cholesterol level as covariates, IgE was positively and independently associated with any cardiovascular disease (p = 0.03). Similar evaluations in women revealed no correlation between IgE and cardiovascular disease by either univariate or multivariable analysis. These data indicate that IgE may be an independent marker for cardiovascular disease in men, and thus suggest IgE-mediated events may play a role in the pathogenesis of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)964-968
Number of pages5
JournalThe American Journal of Medicine
Volume82
Issue number5
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Immunoglobulin E
Cardiovascular Diseases
Population
Peripheral Arterial Disease
Stroke
Myocardial Infarction
Blood Pressure
Platelet Activation
Spasm
Serum
LDL Cholesterol
Fasting
Logistic Models
Smoking
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ige and cardiovascular disease. Results from a population-based study. / Criqui, Michael H.; Lee, Edwin R.; Hamburger, Robert N.; Klauber, Melville R.; Coughlin, Steven Scott.

In: The American Journal of Medicine, Vol. 82, No. 5, 01.01.1987, p. 964-968.

Research output: Contribution to journalArticle

Criqui, Michael H. ; Lee, Edwin R. ; Hamburger, Robert N. ; Klauber, Melville R. ; Coughlin, Steven Scott. / Ige and cardiovascular disease. Results from a population-based study. In: The American Journal of Medicine. 1987 ; Vol. 82, No. 5. pp. 964-968.
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