IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in tumor-initiating cells and in the tumor microenvironment

Jennifer W. Bradford, Albert S. Baldwin

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Scopus citations

Abstract

The IKK/nuclear factor-kappaB pathway (NF-κB) is critical in proper immune function, cell survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-κB is crucial for both innate and adaptive immunity, defective regulation of this master transcriptional regulator is seen in a variety of diseases including autoimmune disease, neurodegenerative disease, and, important to this review, cancer. While NF-κB functions in cancer to promote a number of critical oncogenic functions, here we discuss the importance of the NF-κB signaling pathway in contributing to cancer through promotion of the tumor microenvironment and through maintenance/expansion of tumor-initiating cells, processes that appear to be functionally interrelated.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages125-145
Number of pages21
DOIs
Publication statusPublished - 2014
Externally publishedYes

Publication series

NameAdvances in Cancer Research
Volume121
ISSN (Print)0065-230X

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Keywords

  • Cancer-associated fibroblast
  • Cytokine
  • Nuclear factor-kappaB
  • Regulatory T lymphocyte
  • Stroma
  • Tumor-associated macrophage
  • Tumor-initiating cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bradford, J. W., & Baldwin, A. S. (2014). IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in tumor-initiating cells and in the tumor microenvironment. In Advances in Cancer Research (pp. 125-145). (Advances in Cancer Research; Vol. 121). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-800249-0.00003-2