TY - CHAP
T1 - IKK/Nuclear Factor-kappaB and Oncogenesis
T2 - Roles in tumor-initiating cells and in the tumor microenvironment
AU - Bradford, Jennifer W.
AU - Baldwin, Albert S.
N1 - Funding Information:
We thank members of the Baldwin lab for insightful discussion pertaining to this review, and we thank Scott Bradford for assisting with the figures. The authors’ work is funded by NCI Grants CA73756 and CA75080, NIH Grants AI35098 and F32 CA162628-01, and the Waxman Cancer Research Foundation. The authors declare no conflict of interest.
PY - 2014
Y1 - 2014
N2 - The IKK/nuclear factor-kappaB pathway (NF-κB) is critical in proper immune function, cell survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-κB is crucial for both innate and adaptive immunity, defective regulation of this master transcriptional regulator is seen in a variety of diseases including autoimmune disease, neurodegenerative disease, and, important to this review, cancer. While NF-κB functions in cancer to promote a number of critical oncogenic functions, here we discuss the importance of the NF-κB signaling pathway in contributing to cancer through promotion of the tumor microenvironment and through maintenance/expansion of tumor-initiating cells, processes that appear to be functionally interrelated.
AB - The IKK/nuclear factor-kappaB pathway (NF-κB) is critical in proper immune function, cell survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-κB is crucial for both innate and adaptive immunity, defective regulation of this master transcriptional regulator is seen in a variety of diseases including autoimmune disease, neurodegenerative disease, and, important to this review, cancer. While NF-κB functions in cancer to promote a number of critical oncogenic functions, here we discuss the importance of the NF-κB signaling pathway in contributing to cancer through promotion of the tumor microenvironment and through maintenance/expansion of tumor-initiating cells, processes that appear to be functionally interrelated.
KW - Cancer-associated fibroblast
KW - Cytokine
KW - Nuclear factor-kappaB
KW - Regulatory T lymphocyte
KW - Stroma
KW - Tumor-associated macrophage
KW - Tumor-initiating cell
UR - http://www.scopus.com/inward/record.url?scp=84901495560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901495560&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-800249-0.00003-2
DO - 10.1016/B978-0-12-800249-0.00003-2
M3 - Chapter
C2 - 24889530
AN - SCOPUS:84901495560
T3 - Advances in Cancer Research
SP - 125
EP - 145
BT - Advances in Cancer Research
PB - Academic Press Inc.
ER -
