IKK/Nuclear Factor-kappaB and Oncogenesis

Roles in tumor-initiating cells and in the tumor microenvironment

Jennifer Webster Bradford, Albert S. Baldwin

Research output: Chapter in Book/Report/Conference proceedingChapter

41 Citations (Scopus)

Abstract

The IKK/nuclear factor-kappaB pathway (NF-κB) is critical in proper immune function, cell survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-κB is crucial for both innate and adaptive immunity, defective regulation of this master transcriptional regulator is seen in a variety of diseases including autoimmune disease, neurodegenerative disease, and, important to this review, cancer. While NF-κB functions in cancer to promote a number of critical oncogenic functions, here we discuss the importance of the NF-κB signaling pathway in contributing to cancer through promotion of the tumor microenvironment and through maintenance/expansion of tumor-initiating cells, processes that appear to be functionally interrelated.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages125-145
Number of pages21
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Publication series

NameAdvances in Cancer Research
Volume121
ISSN (Print)0065-230X

Fingerprint

Tumor Microenvironment
Neoplastic Stem Cells
Carcinogenesis
Neoplasms
Neuronal Plasticity
Critical Pathways
Adaptive Immunity
Innate Immunity
Neurodegenerative Diseases
Autoimmune Diseases
Cell Survival
Maintenance
Cell Proliferation
Apoptosis

Keywords

  • Cancer-associated fibroblast
  • Cytokine
  • Nuclear factor-kappaB
  • Regulatory T lymphocyte
  • Stroma
  • Tumor-associated macrophage
  • Tumor-initiating cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bradford, J. W., & Baldwin, A. S. (2014). IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in tumor-initiating cells and in the tumor microenvironment. In Advances in Cancer Research (pp. 125-145). (Advances in Cancer Research; Vol. 121). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-800249-0.00003-2

IKK/Nuclear Factor-kappaB and Oncogenesis : Roles in tumor-initiating cells and in the tumor microenvironment. / Bradford, Jennifer Webster; Baldwin, Albert S.

Advances in Cancer Research. Academic Press Inc., 2014. p. 125-145 (Advances in Cancer Research; Vol. 121).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bradford, JW & Baldwin, AS 2014, IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in tumor-initiating cells and in the tumor microenvironment. in Advances in Cancer Research. Advances in Cancer Research, vol. 121, Academic Press Inc., pp. 125-145. https://doi.org/10.1016/B978-0-12-800249-0.00003-2
Bradford JW, Baldwin AS. IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in tumor-initiating cells and in the tumor microenvironment. In Advances in Cancer Research. Academic Press Inc. 2014. p. 125-145. (Advances in Cancer Research). https://doi.org/10.1016/B978-0-12-800249-0.00003-2
Bradford, Jennifer Webster ; Baldwin, Albert S. / IKK/Nuclear Factor-kappaB and Oncogenesis : Roles in tumor-initiating cells and in the tumor microenvironment. Advances in Cancer Research. Academic Press Inc., 2014. pp. 125-145 (Advances in Cancer Research).
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