IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity

Li X. Zhu, Sherven Sharma, Brian Gardner, Brian Escuadro, Kimberly Calica Atianzar, Donald P. Tashkin, Steven M. Dubinett

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Sigma receptors are unique endoplasmic reticulum proteins that mediate signaling for a variety of drugs. We determined the effect of sigma1 receptor agonists on immune responses in a syngeneic lung cancer model. Sigma1 receptor agonists, including cocaine, up-regulated splenocyte IL-10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive manner. In vivo, sigma1 receptor agonists promoted tumor growth and induced IL-10 at the tumor site. Increased tumor growth was prevented by administration of specific Abs to IL-10 or by administration of specific sigma1 receptor antagonists. We report that sigma1 receptor ligands, including cocaine, augment tumor growth through an IL-10 dependent mechanism.

Original languageEnglish (US)
Pages (from-to)3585-3591
Number of pages7
JournalJournal of Immunology
Volume170
Issue number7
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Interleukin-10
Immunity
sigma Receptors
Cocaine
Neoplasms
Growth
Pertussis Toxin
Endoplasmic Reticulum
Lung Neoplasms
Proteins
Ligands
Messenger RNA
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Zhu, L. X., Sharma, S., Gardner, B., Escuadro, B., Atianzar, K. C., Tashkin, D. P., & Dubinett, S. M. (2003). IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity. Journal of Immunology, 170(7), 3585-3591. https://doi.org/10.4049/jimmunol.170.7.3585

IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity. / Zhu, Li X.; Sharma, Sherven; Gardner, Brian; Escuadro, Brian; Atianzar, Kimberly Calica; Tashkin, Donald P.; Dubinett, Steven M.

In: Journal of Immunology, Vol. 170, No. 7, 01.04.2003, p. 3585-3591.

Research output: Contribution to journalArticle

Zhu, LX, Sharma, S, Gardner, B, Escuadro, B, Atianzar, KC, Tashkin, DP & Dubinett, SM 2003, 'IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity', Journal of Immunology, vol. 170, no. 7, pp. 3585-3591. https://doi.org/10.4049/jimmunol.170.7.3585
Zhu, Li X. ; Sharma, Sherven ; Gardner, Brian ; Escuadro, Brian ; Atianzar, Kimberly Calica ; Tashkin, Donald P. ; Dubinett, Steven M. / IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity. In: Journal of Immunology. 2003 ; Vol. 170, No. 7. pp. 3585-3591.
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