IL-10 mediates sigma1 receptor-dependent suppression of antitumor immunity

Li X. Zhu, Sherven Sharma, Brian Gardner, Brian Escuadro, Kimberly Atianzar, Donald P. Tashkin, Steven M. Dubinett

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Sigma receptors are unique endoplasmic reticulum proteins that mediate signaling for a variety of drugs. We determined the effect of sigma1 receptor agonists on immune responses in a syngeneic lung cancer model. Sigma1 receptor agonists, including cocaine, up-regulated splenocyte IL-10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive manner. In vivo, sigma1 receptor agonists promoted tumor growth and induced IL-10 at the tumor site. Increased tumor growth was prevented by administration of specific Abs to IL-10 or by administration of specific sigma1 receptor antagonists. We report that sigma1 receptor ligands, including cocaine, augment tumor growth through an IL-10 dependent mechanism.

Original languageEnglish (US)
Pages (from-to)3585-3591
Number of pages7
JournalJournal of Immunology
Volume170
Issue number7
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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