Abstract
Sigma receptors are unique endoplasmic reticulum proteins that mediate signaling for a variety of drugs. We determined the effect of sigma1 receptor agonists on immune responses in a syngeneic lung cancer model. Sigma1 receptor agonists, including cocaine, up-regulated splenocyte IL-10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive manner. In vivo, sigma1 receptor agonists promoted tumor growth and induced IL-10 at the tumor site. Increased tumor growth was prevented by administration of specific Abs to IL-10 or by administration of specific sigma1 receptor antagonists. We report that sigma1 receptor ligands, including cocaine, augment tumor growth through an IL-10 dependent mechanism.
Original language | English (US) |
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Pages (from-to) | 3585-3591 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 170 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology