IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

Steven A. Rosenberg; Claude Sportès; Mojgan Ahmadzadeh; Terry J. Fry; Lien T. Ngo; Susan L. Schwarz; Maryalice Stetler-Stevenson; Kathleen E. Morton; Sharon A. Mavroukakis; Michel Morre; Renaud Buffet; Crystal L. Mackall; Ronald E. Gress

doi:10.1080/03601270600564088

IL-7 administration to humans leads to expansion of CD8⁺ and CD4⁺ cells but a relative decrease of CD4⁺ T-regulatory cells

Steven A. Rosenberg, Claude Sportès, Mojgan Ahmadzadeh, Terry J. Fry, Lien T. Ngo, Susan L. Schwarz, Maryalice Stetler-Stevenson, Kathleen E. Morton, Sharon A. Mavroukakis, Michel Morre, Renaud Buffet, Crystal L. Mackall, Ronald E. Gress

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

370 Scopus citations

Abstract

Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8 lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4 and CD8 lymphocytes along with a decrease in the percentage of CD4 T-regulatory cells. These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia.

Original language	English (US)
Pages (from-to)	313-319
Number of pages	7
Journal	Journal of Immunotherapy
Volume	29
Issue number	3
DOIs	https://doi.org/10.1080/03601270600564088
State	Published - May 2006

Keywords

Human lymphocytes
Interleukin-7
Lymphopoiesis
Regulatory T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/03601270600564088

Cite this

Rosenberg, S. A., Sportès, C., Ahmadzadeh, M., Fry, T. J., Ngo, L. T., Schwarz, S. L., Stetler-Stevenson, M., Morton, K. E., Mavroukakis, S. A., Morre, M., Buffet, R., Mackall, C. L., & Gress, R. E. (2006). IL-7 administration to humans leads to expansion of CD8⁺ and CD4⁺ cells but a relative decrease of CD4⁺ T-regulatory cells. Journal of Immunotherapy, 29(3), 313-319. https://doi.org/10.1080/03601270600564088

Rosenberg, SA, Sportès, C, Ahmadzadeh, M, Fry, TJ, Ngo, LT, Schwarz, SL, Stetler-Stevenson, M, Morton, KE, Mavroukakis, SA, Morre, M, Buffet, R, Mackall, CL & Gress, RE 2006, 'IL-7 administration to humans leads to expansion of CD8⁺ and CD4⁺ cells but a relative decrease of CD4⁺ T-regulatory cells', Journal of Immunotherapy, vol. 29, no. 3, pp. 313-319. https://doi.org/10.1080/03601270600564088

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abstract = "Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8 lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4 and CD8 lymphocytes along with a decrease in the percentage of CD4 T-regulatory cells. These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia.",

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AU - Fry, Terry J.

AU - Ngo, Lien T.

AU - Schwarz, Susan L.

AU - Stetler-Stevenson, Maryalice

AU - Morton, Kathleen E.

AU - Mavroukakis, Sharon A.

AU - Morre, Michel

AU - Buffet, Renaud

AU - Mackall, Crystal L.

AU - Gress, Ronald E.

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AB - Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8 lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4 and CD8 lymphocytes along with a decrease in the percentage of CD4 T-regulatory cells. These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia.

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KW - Lymphopoiesis

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