Image-based numerical modeling of HIFU-induced lesions

Mohamed K. Almekkaway, Islam A. Shehata, Alyona Haritonova, John Ballard, Andrew Casper, Emad Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Atherosclerosis is a chronic vascular disease affecting large and medium sized arteries. Several treatment options are already available for treatment of this disease. Targeting atherosclerotic plaques by high intensity focused ultrasound (HIFU) using dual mode ultrasound arrays (DMUA) was recently introduced in literature. We present a finite difference time domain (FDTD) simulation modeling of the wave propagation in heterogeneous medium from the surface of a 3.5MHz array prototype with 32-elements. After segmentation of the ultrasound image obtained for the treatment region in-vivo, we integrated this anatomical information into our simulation to account for different parameters that may be caused by these multi-region anatomical complexities. The simulation program showed that HIFU was able to induce damage in the prefocal region instead of the target area. The HIFU lesions, as predicted by our simulation, were well correlated with the actual damage detected in histology.

Original languageEnglish (US)
Title of host publicationProceedings from the 13th International Symposium on Therapeutic Ultrasound
EditorsJ. Brian Fowlkes, Vasant A. Salgaonkar
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414846
DOIs
StatePublished - Mar 1 2017
Event13th International Symposium on Therapeutic Ultrasound, ISTU 2013 - Shanghai, China
Duration: May 12 2013May 15 2013

Publication series

NameAIP Conference Proceedings
Volume1816
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference13th International Symposium on Therapeutic Ultrasound, ISTU 2013
CountryChina
CityShanghai
Period5/12/135/15/13

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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