Imatinib mesylate in the treatment of chronic myelogenous leukemia

Gautam Borthakur, Jorge E. Cortes

Research output: Contribution to journalReview article

Abstract

Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase, suppressing the Philadelphia chromosome-positive clone in chronic myelogenous leukemia (CML). Clinical studies of imatinib have yielded impressive results in the treatment of all phases of CML. With the higher rates of complete cytogenetic response with imatinib, molecular monitoring of disease has become mandatory in assessing response and determining prognosis. The practical aspects of the treatment of CML with imatinib are discussed. The emergence of imatinib resistance, albeit in a small percentage of patients, has prompted an evaluation of innovative treatment strategies.

Original languageEnglish (US)
Pages (from-to)411-419
Number of pages9
JournalInternational Journal of Hematology
Volume79
Issue number5
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Fingerprint

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Chronic Phase
Therapeutics
Philadelphia Chromosome
Cytogenetics
Protein-Tyrosine Kinases
Clone Cells
Imatinib Mesylate

Keywords

  • Chronic myeloid leukemia
  • Imatinib

ASJC Scopus subject areas

  • Hematology

Cite this

@article{abf703e0bb3548b5a0ef192561fce479,
title = "Imatinib mesylate in the treatment of chronic myelogenous leukemia",
abstract = "Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase, suppressing the Philadelphia chromosome-positive clone in chronic myelogenous leukemia (CML). Clinical studies of imatinib have yielded impressive results in the treatment of all phases of CML. With the higher rates of complete cytogenetic response with imatinib, molecular monitoring of disease has become mandatory in assessing response and determining prognosis. The practical aspects of the treatment of CML with imatinib are discussed. The emergence of imatinib resistance, albeit in a small percentage of patients, has prompted an evaluation of innovative treatment strategies.",
keywords = "Chronic myeloid leukemia, Imatinib",
author = "Gautam Borthakur and Cortes, {Jorge E.}",
year = "2004",
month = "6",
day = "1",
doi = "10.1532/IJH97.04054",
language = "English (US)",
volume = "79",
pages = "411--419",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "5",

}