TY - JOUR
T1 - Immunogenicity of protein therapeutics and the interplay between tolerance and antibody responses
AU - Barbosa, Maria D.F.S.
AU - Celis, Esteban
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Patients can mount sustained immune responses to protein therapeutics with the production of neutralizing antibodies (NAbs) that can compromise efficacy or safety of these drugs. Dendritic cells (DCs) are required for immunoglobulin (Ig) isotype switching and the production of IgG, a process involving presentation of MHC class II binding epitopes to helper T cells (CD4+ T cells) and subsequent B cell activation. DCs, CD4+ T cells and MHC class II binding epitopes are also involved in self-tolerance. While many assay formats are available for reliable antibody detection, the complex in vivo interplay between immunogenicity and tolerance hinders accurate pre-clinical predictions of protein drug immunogenicity to humans.
AB - Patients can mount sustained immune responses to protein therapeutics with the production of neutralizing antibodies (NAbs) that can compromise efficacy or safety of these drugs. Dendritic cells (DCs) are required for immunoglobulin (Ig) isotype switching and the production of IgG, a process involving presentation of MHC class II binding epitopes to helper T cells (CD4+ T cells) and subsequent B cell activation. DCs, CD4+ T cells and MHC class II binding epitopes are also involved in self-tolerance. While many assay formats are available for reliable antibody detection, the complex in vivo interplay between immunogenicity and tolerance hinders accurate pre-clinical predictions of protein drug immunogenicity to humans.
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U2 - 10.1016/j.drudis.2007.06.005
DO - 10.1016/j.drudis.2007.06.005
M3 - Review article
C2 - 17706550
AN - SCOPUS:34547743906
SN - 1359-6446
VL - 12
SP - 674
EP - 681
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 15-16
ER -