Immunological considerations of modern animal models of malignant primary brain tumors

Michael E. Sughrue, Isaac Yang, Ari J. Kane, Martin J. Rutkowski, Shanna Fang, C. David James, Andrew T. Parsa

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Recent advances in animal models of glioma have facilitated a better understanding of biological mechanisms underlying gliomagenesis and glioma progression. The limitations of existing therapy, including surgery, chemotherapy, and radiotherapy, have prompted numerous investigators to search for new therapeutic approaches to improve quantity and quality of survival from these aggressive lesions. One of these approaches involves triggering a tumor specific immune response. However, a difficulty in this approach is the the scarcity of animal models of primary CNS neoplasms which faithfully recapitulate these tumors and their interaction with the host's immune system. In this article, we review the existing methods utilized to date for modeling gliomas in rodents, with a focus on the known as well as potential immunological aspects of these models. As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention.

Original languageEnglish (US)
Article number1479
Number of pages1
JournalJournal of Translational Medicine
Volume7
DOIs
StatePublished - Oct 8 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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