Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan; R. Toni; B. D. Clark; J. G. Cannon; A. R. Shaw; C. A. Dinarello; S. Reichlin

doi:10.1016/0006-8993(90)90445-H

Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan, R. Toni, B. D. Clark, J. G. Cannon, A. R. Shaw, C. A. Dinarello, S. Reichlin

Research output: Contribution to journal › Article › peer-review

336 Scopus citations

Abstract

To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

Original language	English (US)
Pages (from-to)	135-140
Number of pages	6
Journal	Brain Research
Volume	514
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(90)90445-H
State	Published - Apr 23 1990
Externally published	Yes

Keywords

Cytokine
Hippocampus
Hypothalamus
Immunocytochemistry
Interleukin-1
Olfactory tubercle

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(90)90445-H

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title = "Immunoreactive interleukin-1β localization in the rat forebrain",

abstract = "To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.",

keywords = "Cytokine, Hippocampus, Hypothalamus, Immunocytochemistry, Interleukin-1, Olfactory tubercle",

author = "Lechan, {Ronald M.} and R. Toni and Clark, {B. D.} and Cannon, {J. G.} and Shaw, {A. R.} and Dinarello, {C. A.} and S. Reichlin",

year = "1990",

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T1 - Immunoreactive interleukin-1β localization in the rat forebrain

AU - Lechan, Ronald M.

AU - Toni, R.

AU - Clark, B. D.

AU - Cannon, J. G.

AU - Shaw, A. R.

AU - Dinarello, C. A.

AU - Reichlin, S.

PY - 1990/4/23

Y1 - 1990/4/23

N2 - To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

AB - To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

KW - Cytokine

KW - Hippocampus

KW - Hypothalamus

KW - Immunocytochemistry

KW - Interleukin-1

KW - Olfactory tubercle

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Immunoreactive interleukin-1β localization in the rat forebrain

Abstract

Keywords

ASJC Scopus subject areas

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