Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation

Alana Althage, Bernhard Odermatt, Demetrius Moskophidis, Thomas Kündig, Urs Hoffman‐Rohrer Hans Hengartner, Rolf M. Zinkernagel

Research output: Contribution to journalArticle

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Abstract

Lymphocytic choriomeningitis virus (LCMV) may cause a severe immunosuppression in mice. Its pathogenesis is apparently dependent on LCMV‐specific CD8 effector T cells that mediate the destruction of virus‐infected cells which are normally essentially involved in immune responses. Evaluation of various LCMV isolates in this study established a general correlation between their tropism for lymphohemopoietic cells and immunosuppression. When immune responses were assessed as the capacity of mice to mount an anti‐vaccinia virus cytotoxic T cell response or an IgG response to vesicular stomatitis virus (VSV), after a primary LCMV infection, LCMV‐Armstrong, WE, Clone 13 and Docile were increasingly immunosuppressive in a dose‐dependent fashion with respect to both extent and duration. Analysis of lymphocyte subpopulations showed variable effects of the various LCMV isolates that did not reveal patterns readily explaining immunosuppression. To evaluate whether LCMV infection affected T and/or B cell functions directly or whether antigen presentation was impaired, adoptive transfer experiments were performed. Untreated or irradiated but uninfected normal recipient mice receiving adoptively transferred T or B cells from LCMV‐WE or Docile‐infected immunosuppressed donor mice responded within 30%–100% of normal ranges in both assay systems. In contrast, when T or B cells from normal donors were transferred to irradiated or non‐irradiated LCMV‐immunosuppressed recipients, they failed to mount a significant cytotoxic T cell response against vaccinia virus or an IgG response to VSV. Thus, the T and B cells from LCMV‐immunosuppressed mice were able to function within normal ranges; in contrast, histologically and functionally, antigen presentation was severely impaired in LCMV‐immunosuppressed mice.

Original languageEnglish (US)
Pages (from-to)1803-1812
Number of pages10
JournalEuropean Journal of Immunology
Volume22
Issue number7
DOIs
StatePublished - Jul 1992

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Lymphocytic choriomeningitis virus
B-Lymphocyte Subsets
Antigen Presentation
Virus Diseases
Immunosuppression
T-Lymphocytes
B-Lymphocytes
Vesicular Stomatitis
Viruses
Reference Values
Immunoglobulin G
Tropism
Adoptive Transfer
Vaccinia virus
Lymphocyte Subsets
Immunosuppressive Agents
Clone Cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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Immunosuppression by lymphocytic choriomeningitis virus infection : competent effector T and B cells but impaired antigen presentation. / Althage, Alana; Odermatt, Bernhard; Moskophidis, Demetrius; Kündig, Thomas; Hengartner, Urs Hoffman‐Rohrer Hans; Zinkernagel, Rolf M.

In: European Journal of Immunology, Vol. 22, No. 7, 07.1992, p. 1803-1812.

Research output: Contribution to journalArticle

Althage, Alana ; Odermatt, Bernhard ; Moskophidis, Demetrius ; Kündig, Thomas ; Hengartner, Urs Hoffman‐Rohrer Hans ; Zinkernagel, Rolf M. / Immunosuppression by lymphocytic choriomeningitis virus infection : competent effector T and B cells but impaired antigen presentation. In: European Journal of Immunology. 1992 ; Vol. 22, No. 7. pp. 1803-1812.
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