Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes

Adviye Ergul, Sherif Hafez, Abdelrahman Fouda, Susan C. Fagan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Human ischemic stroke is very complex, and no single preclinical model can comprise all the variables known to contribute to stroke injury and recovery. Hypertension, diabetes, and hyperlipidemia are leading comorbidities in stroke patients. The use of predominantly young adult and healthy animals in experimental stroke research has created a barrier for translation of findings to patients. As such, more and more disease models are being incorporated into the research design. This review highlights the major strengths and weaknesses of the most commonly used animal models of these conditions in preclinical stroke research. The goal is to provide guidance in choosing, reporting, and executing appropriate disease models that will be subjected to different models of stroke injury.

Original languageEnglish (US)
Pages (from-to)248-260
Number of pages13
JournalTranslational Stroke Research
Volume7
Issue number4
DOIs
StatePublished - Aug 1 2016

Fingerprint

Comorbidity
Stroke
Hypertension
Wounds and Injuries
Research
Hyperlipidemias
Young Adult
Research Design
Animal Models

Keywords

  • Diabetes
  • Hypertension
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research : Focus on Hypertension and Diabetes. / Ergul, Adviye; Hafez, Sherif; Fouda, Abdelrahman; Fagan, Susan C.

In: Translational Stroke Research, Vol. 7, No. 4, 01.08.2016, p. 248-260.

Research output: Contribution to journalArticle

Ergul, Adviye ; Hafez, Sherif ; Fouda, Abdelrahman ; Fagan, Susan C. / Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research : Focus on Hypertension and Diabetes. In: Translational Stroke Research. 2016 ; Vol. 7, No. 4. pp. 248-260.
@article{e362708389174476ab038e9df9fe4ed8,
title = "Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes",
abstract = "Human ischemic stroke is very complex, and no single preclinical model can comprise all the variables known to contribute to stroke injury and recovery. Hypertension, diabetes, and hyperlipidemia are leading comorbidities in stroke patients. The use of predominantly young adult and healthy animals in experimental stroke research has created a barrier for translation of findings to patients. As such, more and more disease models are being incorporated into the research design. This review highlights the major strengths and weaknesses of the most commonly used animal models of these conditions in preclinical stroke research. The goal is to provide guidance in choosing, reporting, and executing appropriate disease models that will be subjected to different models of stroke injury.",
keywords = "Diabetes, Hypertension, Stroke",
author = "Adviye Ergul and Sherif Hafez and Abdelrahman Fouda and Fagan, {Susan C.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1007/s12975-016-0464-8",
language = "English (US)",
volume = "7",
pages = "248--260",
journal = "Translational Stroke Research",
issn = "1868-4483",
publisher = "Springer US",
number = "4",

}

TY - JOUR

T1 - Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research

T2 - Focus on Hypertension and Diabetes

AU - Ergul, Adviye

AU - Hafez, Sherif

AU - Fouda, Abdelrahman

AU - Fagan, Susan C.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Human ischemic stroke is very complex, and no single preclinical model can comprise all the variables known to contribute to stroke injury and recovery. Hypertension, diabetes, and hyperlipidemia are leading comorbidities in stroke patients. The use of predominantly young adult and healthy animals in experimental stroke research has created a barrier for translation of findings to patients. As such, more and more disease models are being incorporated into the research design. This review highlights the major strengths and weaknesses of the most commonly used animal models of these conditions in preclinical stroke research. The goal is to provide guidance in choosing, reporting, and executing appropriate disease models that will be subjected to different models of stroke injury.

AB - Human ischemic stroke is very complex, and no single preclinical model can comprise all the variables known to contribute to stroke injury and recovery. Hypertension, diabetes, and hyperlipidemia are leading comorbidities in stroke patients. The use of predominantly young adult and healthy animals in experimental stroke research has created a barrier for translation of findings to patients. As such, more and more disease models are being incorporated into the research design. This review highlights the major strengths and weaknesses of the most commonly used animal models of these conditions in preclinical stroke research. The goal is to provide guidance in choosing, reporting, and executing appropriate disease models that will be subjected to different models of stroke injury.

KW - Diabetes

KW - Hypertension

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=84962253278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962253278&partnerID=8YFLogxK

U2 - 10.1007/s12975-016-0464-8

DO - 10.1007/s12975-016-0464-8

M3 - Article

C2 - 27026092

AN - SCOPUS:84962253278

VL - 7

SP - 248

EP - 260

JO - Translational Stroke Research

JF - Translational Stroke Research

SN - 1868-4483

IS - 4

ER -