Impact of obesity on coronary microvascular function in the Zucker rat

Rajan Prakash, James Mintz, David W Stepp

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To test the hypothesis that vasomotor control is impaired in the coronary circulation of prediabetic obese (OZR) relative to lean Zucker rats (LZR). Methods: Cardiac function was assessed with in vivo measures of cardiac output and microvascular structure and function was assessed in vitro using videomicroscopic techniques. Results: OZR showed a marked hyperdynamic circulation with an increased cardiac output and elevated stroke volume. Contrary to the stated hypothesis, the authors found no diminution of vasodilator function and no augmentation of vasoconstriction. Indeed, dilation to acetylcholine was potentiated and vasoconstriction to endothelin was reduced in OZR compared to LZR. Structural characteristics of small coronary arteries were similar between LZR and OZR. Conclusions: Taken together, these results indicate that obesity, as manifested in the prediabetic OZR, does not impair coronary vasomotor control. This lack of dysfunction in the presence of the same risk factors that affect other beds may reflect a reversal of vascular injury by the increased metabolism and coronary blood flow caused by hyperdynamic cardiac function early in obesity.

Original languageEnglish (US)
Pages (from-to)389-396
Number of pages8
JournalMicrocirculation
Volume13
Issue number5
DOIs
StatePublished - Jul 1 2006

Fingerprint

Zucker Rats
Obesity
Vasoconstriction
Cardiac Output
Coronary Circulation
Vascular System Injuries
Endothelins
Vasodilator Agents
Stroke Volume
Acetylcholine
Dilatation
Coronary Vessels

Keywords

  • Cardiac output
  • Endothelin
  • Microcirculation
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Impact of obesity on coronary microvascular function in the Zucker rat. / Prakash, Rajan; Mintz, James; Stepp, David W.

In: Microcirculation, Vol. 13, No. 5, 01.07.2006, p. 389-396.

Research output: Contribution to journalArticle

Prakash, Rajan ; Mintz, James ; Stepp, David W. / Impact of obesity on coronary microvascular function in the Zucker rat. In: Microcirculation. 2006 ; Vol. 13, No. 5. pp. 389-396.
@article{b5ac029e5d6b4f3283a0d79f5c51aef9,
title = "Impact of obesity on coronary microvascular function in the Zucker rat",
abstract = "Objective: To test the hypothesis that vasomotor control is impaired in the coronary circulation of prediabetic obese (OZR) relative to lean Zucker rats (LZR). Methods: Cardiac function was assessed with in vivo measures of cardiac output and microvascular structure and function was assessed in vitro using videomicroscopic techniques. Results: OZR showed a marked hyperdynamic circulation with an increased cardiac output and elevated stroke volume. Contrary to the stated hypothesis, the authors found no diminution of vasodilator function and no augmentation of vasoconstriction. Indeed, dilation to acetylcholine was potentiated and vasoconstriction to endothelin was reduced in OZR compared to LZR. Structural characteristics of small coronary arteries were similar between LZR and OZR. Conclusions: Taken together, these results indicate that obesity, as manifested in the prediabetic OZR, does not impair coronary vasomotor control. This lack of dysfunction in the presence of the same risk factors that affect other beds may reflect a reversal of vascular injury by the increased metabolism and coronary blood flow caused by hyperdynamic cardiac function early in obesity.",
keywords = "Cardiac output, Endothelin, Microcirculation, Nitric oxide",
author = "Rajan Prakash and James Mintz and Stepp, {David W}",
year = "2006",
month = "7",
day = "1",
doi = "10.1080/10739680600745919",
language = "English (US)",
volume = "13",
pages = "389--396",
journal = "Microcirculation",
issn = "1073-9688",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Impact of obesity on coronary microvascular function in the Zucker rat

AU - Prakash, Rajan

AU - Mintz, James

AU - Stepp, David W

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Objective: To test the hypothesis that vasomotor control is impaired in the coronary circulation of prediabetic obese (OZR) relative to lean Zucker rats (LZR). Methods: Cardiac function was assessed with in vivo measures of cardiac output and microvascular structure and function was assessed in vitro using videomicroscopic techniques. Results: OZR showed a marked hyperdynamic circulation with an increased cardiac output and elevated stroke volume. Contrary to the stated hypothesis, the authors found no diminution of vasodilator function and no augmentation of vasoconstriction. Indeed, dilation to acetylcholine was potentiated and vasoconstriction to endothelin was reduced in OZR compared to LZR. Structural characteristics of small coronary arteries were similar between LZR and OZR. Conclusions: Taken together, these results indicate that obesity, as manifested in the prediabetic OZR, does not impair coronary vasomotor control. This lack of dysfunction in the presence of the same risk factors that affect other beds may reflect a reversal of vascular injury by the increased metabolism and coronary blood flow caused by hyperdynamic cardiac function early in obesity.

AB - Objective: To test the hypothesis that vasomotor control is impaired in the coronary circulation of prediabetic obese (OZR) relative to lean Zucker rats (LZR). Methods: Cardiac function was assessed with in vivo measures of cardiac output and microvascular structure and function was assessed in vitro using videomicroscopic techniques. Results: OZR showed a marked hyperdynamic circulation with an increased cardiac output and elevated stroke volume. Contrary to the stated hypothesis, the authors found no diminution of vasodilator function and no augmentation of vasoconstriction. Indeed, dilation to acetylcholine was potentiated and vasoconstriction to endothelin was reduced in OZR compared to LZR. Structural characteristics of small coronary arteries were similar between LZR and OZR. Conclusions: Taken together, these results indicate that obesity, as manifested in the prediabetic OZR, does not impair coronary vasomotor control. This lack of dysfunction in the presence of the same risk factors that affect other beds may reflect a reversal of vascular injury by the increased metabolism and coronary blood flow caused by hyperdynamic cardiac function early in obesity.

KW - Cardiac output

KW - Endothelin

KW - Microcirculation

KW - Nitric oxide

UR - http://www.scopus.com/inward/record.url?scp=33745829784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745829784&partnerID=8YFLogxK

U2 - 10.1080/10739680600745919

DO - 10.1080/10739680600745919

M3 - Article

C2 - 16815824

AN - SCOPUS:33745829784

VL - 13

SP - 389

EP - 396

JO - Microcirculation

JF - Microcirculation

SN - 1073-9688

IS - 5

ER -