Impact of subserosal and intramural uterine fibroids that do not distort the endometrial cavity on the outcome of in vitro fertilization- intracytoplasmic sperm injection

Flávio Garcia Oliveira, Vicente G. Abdelmassih, Michael Peter Diamond, Dimitri Dozortsev, Nilson R. Melo, Roger Abdelmassih

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Objective To further evaluate the effects of intramural and subserosal uterine fibroids on the outcome of IVF-ET, when there is no compression of the endometrial cavity. Design Retrospective, matched-control study from January 2000 to October 2001. Setting Private IVF center. Patient(s) Two hundred forty-five women with subserosal and/or intramural fibroids that did not compress the uterine cavity (fibroid group) and 245 women with no evidence of fibroids anywhere in the uterus (control group). Intervention(s) In vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) cycles. Main outcome measure(s) The type of fibroid (intramural, subserosal), number, size (cm), and location of intramural leiomyomas (fundal, corpus) were recorded. Outcomes of IVF-ICSI cycles were compared between the two groups. Result(s) There was no correlation between location and number of uterine fibroids and the outcomes of IVF-ICSI. Patients with subserosal or intramural fibroids <4 cm had IVF-ICSI outcomes (pregnancy, implantation, and abortion rates) similar to those of controls. Patients with intramural fibroids >4.0 cm had lower pregnancy rates than patients with intramural fibroids ≤4.0 cm. There were no statistical differences related to delivery rates (31.5% vs. 32%, respectively) between all patients with fibroids and controls. Premature delivery rates for singleton gestations were 10% vs. 8%, respectively, in all patients with fibroid and controls. Conclusion(s) Patients having subserosal or intramural leiomyomas of <4 cm not encroaching on the uterine cavity have IVF-ICSI outcomes comparable to those of patients without such leiomyomas. Therefore, they might not require myomectomy before being scheduled for assisted reproduction cycles. However, we recommend caution for patients with fibroids >4 cm and that such patients be submitted to treatment before they are enrolled in IVF-ICSI cycles. Whether or not women with fibroids > 4 cm would benefit from fibroid treatment remains to be determined.

Original languageEnglish (US)
Pages (from-to)582-587
Number of pages6
JournalFertility and sterility
Volume81
Issue number3
DOIs
StatePublished - Mar 1 2004

Fingerprint

Intracytoplasmic Sperm Injections
Leiomyoma
Fertilization in Vitro
Pregnancy Rate
Uterus

Keywords

  • IVF-ICSI outcomes
  • Leiomyoma
  • Myomectomy
  • Uterine cavity

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Impact of subserosal and intramural uterine fibroids that do not distort the endometrial cavity on the outcome of in vitro fertilization- intracytoplasmic sperm injection. / Oliveira, Flávio Garcia; Abdelmassih, Vicente G.; Diamond, Michael Peter; Dozortsev, Dimitri; Melo, Nilson R.; Abdelmassih, Roger.

In: Fertility and sterility, Vol. 81, No. 3, 01.03.2004, p. 582-587.

Research output: Contribution to journalArticle

Oliveira, Flávio Garcia ; Abdelmassih, Vicente G. ; Diamond, Michael Peter ; Dozortsev, Dimitri ; Melo, Nilson R. ; Abdelmassih, Roger. / Impact of subserosal and intramural uterine fibroids that do not distort the endometrial cavity on the outcome of in vitro fertilization- intracytoplasmic sperm injection. In: Fertility and sterility. 2004 ; Vol. 81, No. 3. pp. 582-587.
@article{db6e85ce28094bf4804a5017b541ff23,
title = "Impact of subserosal and intramural uterine fibroids that do not distort the endometrial cavity on the outcome of in vitro fertilization- intracytoplasmic sperm injection",
abstract = "Objective To further evaluate the effects of intramural and subserosal uterine fibroids on the outcome of IVF-ET, when there is no compression of the endometrial cavity. Design Retrospective, matched-control study from January 2000 to October 2001. Setting Private IVF center. Patient(s) Two hundred forty-five women with subserosal and/or intramural fibroids that did not compress the uterine cavity (fibroid group) and 245 women with no evidence of fibroids anywhere in the uterus (control group). Intervention(s) In vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) cycles. Main outcome measure(s) The type of fibroid (intramural, subserosal), number, size (cm), and location of intramural leiomyomas (fundal, corpus) were recorded. Outcomes of IVF-ICSI cycles were compared between the two groups. Result(s) There was no correlation between location and number of uterine fibroids and the outcomes of IVF-ICSI. Patients with subserosal or intramural fibroids <4 cm had IVF-ICSI outcomes (pregnancy, implantation, and abortion rates) similar to those of controls. Patients with intramural fibroids >4.0 cm had lower pregnancy rates than patients with intramural fibroids ≤4.0 cm. There were no statistical differences related to delivery rates (31.5{\%} vs. 32{\%}, respectively) between all patients with fibroids and controls. Premature delivery rates for singleton gestations were 10{\%} vs. 8{\%}, respectively, in all patients with fibroid and controls. Conclusion(s) Patients having subserosal or intramural leiomyomas of <4 cm not encroaching on the uterine cavity have IVF-ICSI outcomes comparable to those of patients without such leiomyomas. Therefore, they might not require myomectomy before being scheduled for assisted reproduction cycles. However, we recommend caution for patients with fibroids >4 cm and that such patients be submitted to treatment before they are enrolled in IVF-ICSI cycles. Whether or not women with fibroids > 4 cm would benefit from fibroid treatment remains to be determined.",
keywords = "IVF-ICSI outcomes, Leiomyoma, Myomectomy, Uterine cavity",
author = "Oliveira, {Fl{\'a}vio Garcia} and Abdelmassih, {Vicente G.} and Diamond, {Michael Peter} and Dimitri Dozortsev and Melo, {Nilson R.} and Roger Abdelmassih",
year = "2004",
month = "3",
day = "1",
doi = "10.1016/j.fertnstert.2003.08.034",
language = "English (US)",
volume = "81",
pages = "582--587",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Impact of subserosal and intramural uterine fibroids that do not distort the endometrial cavity on the outcome of in vitro fertilization- intracytoplasmic sperm injection

AU - Oliveira, Flávio Garcia

AU - Abdelmassih, Vicente G.

AU - Diamond, Michael Peter

AU - Dozortsev, Dimitri

AU - Melo, Nilson R.

AU - Abdelmassih, Roger

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Objective To further evaluate the effects of intramural and subserosal uterine fibroids on the outcome of IVF-ET, when there is no compression of the endometrial cavity. Design Retrospective, matched-control study from January 2000 to October 2001. Setting Private IVF center. Patient(s) Two hundred forty-five women with subserosal and/or intramural fibroids that did not compress the uterine cavity (fibroid group) and 245 women with no evidence of fibroids anywhere in the uterus (control group). Intervention(s) In vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) cycles. Main outcome measure(s) The type of fibroid (intramural, subserosal), number, size (cm), and location of intramural leiomyomas (fundal, corpus) were recorded. Outcomes of IVF-ICSI cycles were compared between the two groups. Result(s) There was no correlation between location and number of uterine fibroids and the outcomes of IVF-ICSI. Patients with subserosal or intramural fibroids <4 cm had IVF-ICSI outcomes (pregnancy, implantation, and abortion rates) similar to those of controls. Patients with intramural fibroids >4.0 cm had lower pregnancy rates than patients with intramural fibroids ≤4.0 cm. There were no statistical differences related to delivery rates (31.5% vs. 32%, respectively) between all patients with fibroids and controls. Premature delivery rates for singleton gestations were 10% vs. 8%, respectively, in all patients with fibroid and controls. Conclusion(s) Patients having subserosal or intramural leiomyomas of <4 cm not encroaching on the uterine cavity have IVF-ICSI outcomes comparable to those of patients without such leiomyomas. Therefore, they might not require myomectomy before being scheduled for assisted reproduction cycles. However, we recommend caution for patients with fibroids >4 cm and that such patients be submitted to treatment before they are enrolled in IVF-ICSI cycles. Whether or not women with fibroids > 4 cm would benefit from fibroid treatment remains to be determined.

AB - Objective To further evaluate the effects of intramural and subserosal uterine fibroids on the outcome of IVF-ET, when there is no compression of the endometrial cavity. Design Retrospective, matched-control study from January 2000 to October 2001. Setting Private IVF center. Patient(s) Two hundred forty-five women with subserosal and/or intramural fibroids that did not compress the uterine cavity (fibroid group) and 245 women with no evidence of fibroids anywhere in the uterus (control group). Intervention(s) In vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) cycles. Main outcome measure(s) The type of fibroid (intramural, subserosal), number, size (cm), and location of intramural leiomyomas (fundal, corpus) were recorded. Outcomes of IVF-ICSI cycles were compared between the two groups. Result(s) There was no correlation between location and number of uterine fibroids and the outcomes of IVF-ICSI. Patients with subserosal or intramural fibroids <4 cm had IVF-ICSI outcomes (pregnancy, implantation, and abortion rates) similar to those of controls. Patients with intramural fibroids >4.0 cm had lower pregnancy rates than patients with intramural fibroids ≤4.0 cm. There were no statistical differences related to delivery rates (31.5% vs. 32%, respectively) between all patients with fibroids and controls. Premature delivery rates for singleton gestations were 10% vs. 8%, respectively, in all patients with fibroid and controls. Conclusion(s) Patients having subserosal or intramural leiomyomas of <4 cm not encroaching on the uterine cavity have IVF-ICSI outcomes comparable to those of patients without such leiomyomas. Therefore, they might not require myomectomy before being scheduled for assisted reproduction cycles. However, we recommend caution for patients with fibroids >4 cm and that such patients be submitted to treatment before they are enrolled in IVF-ICSI cycles. Whether or not women with fibroids > 4 cm would benefit from fibroid treatment remains to be determined.

KW - IVF-ICSI outcomes

KW - Leiomyoma

KW - Myomectomy

KW - Uterine cavity

UR - http://www.scopus.com/inward/record.url?scp=1642339604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642339604&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2003.08.034

DO - 10.1016/j.fertnstert.2003.08.034

M3 - Article

C2 - 15037406

AN - SCOPUS:1642339604

VL - 81

SP - 582

EP - 587

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 3

ER -