Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice

Thomas J. McHugh, Kenneth I. Blum, Joseph Zhuo Tsien, Susumu Tonegawa, Matthew A. Wilson

Research output: Contribution to journalArticle

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Abstract

To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus, we have applied multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene. We have discovered that although the CA1 pyramidal cells of these mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields. We have also found a striking deficit in the coordinated firing of pairs of neurons tuned to similar spatial locations. Pairs have uncorrelated firing even if their fields overlap. These results demonstrate that NMDA receptor- mediated synaptic plasticity is necessary for the proper representation of space in the CA1 region of the hippocampus.

Original languageEnglish (US)
Pages (from-to)1339-1349
Number of pages11
JournalCell
Volume87
Issue number7
DOIs
StatePublished - Dec 27 1996
Externally publishedYes

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Neuronal Plasticity
Pyramidal Cells
Knockout Mice
Plasticity
Hippocampus
Gene Knockout Techniques
N-Methyl-D-Aspartate Receptors
Neurons
Electrodes
Genes
Cells
NMDA receptor A1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. / McHugh, Thomas J.; Blum, Kenneth I.; Tsien, Joseph Zhuo; Tonegawa, Susumu; Wilson, Matthew A.

In: Cell, Vol. 87, No. 7, 27.12.1996, p. 1339-1349.

Research output: Contribution to journalArticle

McHugh, Thomas J. ; Blum, Kenneth I. ; Tsien, Joseph Zhuo ; Tonegawa, Susumu ; Wilson, Matthew A. / Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. In: Cell. 1996 ; Vol. 87, No. 7. pp. 1339-1349.
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