Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study

Andrew Siderowf, Danna Jennings, Shirley Eberly, David Oakes, Keith A. Hawkins, Albert Ascherio, Matthew B. Stern, Kenneth Marek, David Russell, Abby Fiocco, Candace Cotto, Kapil Dev Sethi, Paula Jackson, Samuel Frank, Anna Hohler, Cathi A. Thomas, Raymond C. James, Tanya Simuni, Emily Borushko, Matt Stern & 33 others Jacqueline Rick, Robert Hauser, Leyla Khavarian, Theresa McClain, Irene Richard, Cheryl Deely, Grace S. Liang, Liza Reys, Charles H. Adler, Amy K. Duffy, Rachel Saunders-Pullman, Marian L. Evatt, Linda McGinn, Eugene Lai, Shawna Johnson, Farah Atassi, Michael E. DeBakey, Indu Subramanian, Angelina Gratiano, Kathryn Chung, Brenna Lobb, Susan O'Conner, Maria R. Albelo, Carolyn Cioffi, Allison Gadoury, Brian Howard, Valerie Iannucci, Shirley Lasch, Susan Mendick, Donna Miles, Katrina Miles, Emily Virden, Gary Wisniewski

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

To test the association between impaired olfaction and other prodromal features of PD in the Parkinson At-Risk Syndrome Study. The onset of olfactory dysfunction in PD typically precedes motor features, suggesting that olfactory testing could be used as a screening test. A combined strategy that uses other prodromal nonmotor features, along with olfactory testing, may be more efficient than hyposmia alone for detecting the risk of PD. Individuals with no neurological diagnosis completed a mail survey, including the 40-item University of Pennsylvania Smell Identification Test, and questions on prodromal features of PD. The frequency of reported nonmotor features was compared across individuals with and without hyposmia. A total of 4,999 subjects completed and returned the survey and smell test. Of these, 669 were at or below the 15th percentile based on age and gender, indicating hyposmia. Hyposmics were significantly more likely to endorse nonmotor features, including anxiety and depression, constipation, and rapid eye movement sleep behavior disorder symptoms, and to report changes in motor function. Twenty-six percent of subjects with combinations of four or more nonmotor features were hyposmic, compared to 12% for those reporting three or fewer nonmotor features (P < 0.0001). Hyposmia is associated with other nonmotor features of PD in undiagnosed individuals. Further assessment of hyposmic subjects using more specific markers for degeneration, such as dopamine transporter imaging, will evaluate whether combining hyposmia and other nonmotor features is useful in assessing the risk of future neurodegeneration.

Original languageEnglish (US)
Pages (from-to)406-412
Number of pages7
JournalMovement Disorders
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2012

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Smell
REM Sleep Behavior Disorder
Dopamine Plasma Membrane Transport Proteins
Postal Service
Constipation
Anxiety
Depression
Surveys and Questionnaires

Keywords

  • Early detection
  • Nonmotor features
  • Olfaction
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Siderowf, A., Jennings, D., Eberly, S., Oakes, D., Hawkins, K. A., Ascherio, A., ... Wisniewski, G. (2012). Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study. Movement Disorders, 27(3), 406-412. https://doi.org/10.1002/mds.24892

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study. / Siderowf, Andrew; Jennings, Danna; Eberly, Shirley; Oakes, David; Hawkins, Keith A.; Ascherio, Albert; Stern, Matthew B.; Marek, Kenneth; Russell, David; Fiocco, Abby; Cotto, Candace; Sethi, Kapil Dev; Jackson, Paula; Frank, Samuel; Hohler, Anna; Thomas, Cathi A.; James, Raymond C.; Simuni, Tanya; Borushko, Emily; Stern, Matt; Rick, Jacqueline; Hauser, Robert; Khavarian, Leyla; McClain, Theresa; Richard, Irene; Deely, Cheryl; Liang, Grace S.; Reys, Liza; Adler, Charles H.; Duffy, Amy K.; Saunders-Pullman, Rachel; Evatt, Marian L.; McGinn, Linda; Lai, Eugene; Johnson, Shawna; Atassi, Farah; DeBakey, Michael E.; Subramanian, Indu; Gratiano, Angelina; Chung, Kathryn; Lobb, Brenna; O'Conner, Susan; Albelo, Maria R.; Cioffi, Carolyn; Gadoury, Allison; Howard, Brian; Iannucci, Valerie; Lasch, Shirley; Mendick, Susan; Miles, Donna; Miles, Katrina; Virden, Emily; Wisniewski, Gary.

In: Movement Disorders, Vol. 27, No. 3, 01.03.2012, p. 406-412.

Research output: Contribution to journalArticle

Siderowf, A, Jennings, D, Eberly, S, Oakes, D, Hawkins, KA, Ascherio, A, Stern, MB, Marek, K, Russell, D, Fiocco, A, Cotto, C, Sethi, KD, Jackson, P, Frank, S, Hohler, A, Thomas, CA, James, RC, Simuni, T, Borushko, E, Stern, M, Rick, J, Hauser, R, Khavarian, L, McClain, T, Richard, I, Deely, C, Liang, GS, Reys, L, Adler, CH, Duffy, AK, Saunders-Pullman, R, Evatt, ML, McGinn, L, Lai, E, Johnson, S, Atassi, F, DeBakey, ME, Subramanian, I, Gratiano, A, Chung, K, Lobb, B, O'Conner, S, Albelo, MR, Cioffi, C, Gadoury, A, Howard, B, Iannucci, V, Lasch, S, Mendick, S, Miles, D, Miles, K, Virden, E & Wisniewski, G 2012, 'Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study', Movement Disorders, vol. 27, no. 3, pp. 406-412. https://doi.org/10.1002/mds.24892
Siderowf A, Jennings D, Eberly S, Oakes D, Hawkins KA, Ascherio A et al. Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study. Movement Disorders. 2012 Mar 1;27(3):406-412. https://doi.org/10.1002/mds.24892
Siderowf, Andrew ; Jennings, Danna ; Eberly, Shirley ; Oakes, David ; Hawkins, Keith A. ; Ascherio, Albert ; Stern, Matthew B. ; Marek, Kenneth ; Russell, David ; Fiocco, Abby ; Cotto, Candace ; Sethi, Kapil Dev ; Jackson, Paula ; Frank, Samuel ; Hohler, Anna ; Thomas, Cathi A. ; James, Raymond C. ; Simuni, Tanya ; Borushko, Emily ; Stern, Matt ; Rick, Jacqueline ; Hauser, Robert ; Khavarian, Leyla ; McClain, Theresa ; Richard, Irene ; Deely, Cheryl ; Liang, Grace S. ; Reys, Liza ; Adler, Charles H. ; Duffy, Amy K. ; Saunders-Pullman, Rachel ; Evatt, Marian L. ; McGinn, Linda ; Lai, Eugene ; Johnson, Shawna ; Atassi, Farah ; DeBakey, Michael E. ; Subramanian, Indu ; Gratiano, Angelina ; Chung, Kathryn ; Lobb, Brenna ; O'Conner, Susan ; Albelo, Maria R. ; Cioffi, Carolyn ; Gadoury, Allison ; Howard, Brian ; Iannucci, Valerie ; Lasch, Shirley ; Mendick, Susan ; Miles, Donna ; Miles, Katrina ; Virden, Emily ; Wisniewski, Gary. / Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study. In: Movement Disorders. 2012 ; Vol. 27, No. 3. pp. 406-412.
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