Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths

Gregory A. Harshfield; Martha E. Wilson; Coral Hanevold; Gaston K. Kapuku; Lynne Mackey; Delores Gillis; Frank A. Treiber

doi:10.1016/S0895-7061(02)02994-1

Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths

Gregory A. Harshfield, Martha E. Wilson, Coral Hanevold, Gaston K. Kapuku, Lynne Mackey, Delores Gillis, Frank A. Treiber

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. Methods: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P < .03) increase in BP (P < .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P < .05), resulted from a volume-mediated (r = 0.55; P < .002) increase, in BP (P < .001). Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans. Am J Hypertens 2002;15:903-906

Original language	English (US)
Pages (from-to)	903-906
Number of pages	4
Journal	American journal of hypertension
Volume	15
Issue number	10 I
DOIs	https://doi.org/10.1016/S0895-7061(02)02994-1
State	Published - Oct 1 2002

Keywords

African Americans
Blood pressure
Race
Sodium
Stress

ASJC Scopus subject areas

Internal Medicine

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10.1016/S0895-7061(02)02994-1

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title = "Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths",

abstract = "Background: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. Methods: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P < .03) increase in BP (P < .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P < .05), resulted from a volume-mediated (r = 0.55; P < .002) increase, in BP (P < .001). Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans. Am J Hypertens 2002;15:903-906",

keywords = "African Americans, Blood pressure, Race, Sodium, Stress",

author = "Harshfield, {Gregory A.} and Wilson, {Martha E.} and Coral Hanevold and Kapuku, {Gaston K.} and Lynne Mackey and Delores Gillis and Treiber, {Frank A.}",

note = "Funding Information: This study was supported by the grants HL-59954 and HL-64225 from the National Institutes of Health. ",

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doi = "10.1016/S0895-7061(02)02994-1",

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T1 - Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths

AU - Harshfield, Gregory A.

AU - Wilson, Martha E.

AU - Hanevold, Coral

AU - Kapuku, Gaston K.

AU - Mackey, Lynne

AU - Gillis, Delores

AU - Treiber, Frank A.

N1 - Funding Information: This study was supported by the grants HL-59954 and HL-64225 from the National Institutes of Health.

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Background: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. Methods: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P < .03) increase in BP (P < .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P < .05), resulted from a volume-mediated (r = 0.55; P < .002) increase, in BP (P < .001). Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans. Am J Hypertens 2002;15:903-906

AB - Background: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. Methods: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P < .03) increase in BP (P < .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P < .05), resulted from a volume-mediated (r = 0.55; P < .002) increase, in BP (P < .001). Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans. Am J Hypertens 2002;15:903-906

KW - African Americans

KW - Blood pressure

KW - Race

KW - Sodium

KW - Stress

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Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths

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