Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths

Gregory A. Harshfield, Martha E. Wilson, Coral Hanevold, Gaston K. Kapuku, Lynne Mackey, Delores Gillis, Frank A. Treiber

Research output: Contribution to journalArticle

36 Scopus citations


Background: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. Methods: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P < .03) increase in BP (P < .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P < .05), resulted from a volume-mediated (r = 0.55; P < .002) increase, in BP (P < .001). Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans. Am J Hypertens 2002;15:903-906

Original languageEnglish (US)
Pages (from-to)903-906
Number of pages4
JournalAmerican journal of hypertension
Issue number10 I
Publication statusPublished - Oct 1 2002



  • African Americans
  • Blood pressure
  • Race
  • Sodium
  • Stress

ASJC Scopus subject areas

  • Internal Medicine

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