The mechanisms through which stress may contribute to the racial difference in the prevalence of essential hypertension and associated target organ damage remain unclear. This study examined differences in stress-induced pressure natriuresis in 69 black and 52 white normotensives age 14 to 27 years, all with a positive family history of hypertension. Urine samples for sodium excretion were collected before and after a series of tasks (video game challenge, forehead cold stimulation). The average blood pressure across the 2 tasks and the average increase in blood pressure to the 2 tasks were calculated. Blacks had higher mean systolic (131 ± 12 versus 126 ± 12 mm Hg, P<0.02) and diastolic (77 ± 8 versus 72 ± 9 mm Hg, P<0.001) blood pressure and a greater average change in systolic blood pressure (15 ± 9 versus 11 ± 7 mm Hg, P<0.04). This was associated with a smaller change in sodium excretion (2 ± 6 versus 7 ± 10 mEq/h, P<0.002). The change in sodium excretion was related to the change in systolic (r=0.31, P<0.03) and diastolic (r=0.27, P<0.05) blood pressure in whites but not in blacks. Relative wall thickness was greater in blacks (0.31 ± 0.04 versus 0.29 ± 0.03, P<0.002). In conclusion, impaired stress-induced pressure natriuresis in blacks may contribute to racial differences in essential hypertension and its sequelae.
|Original language||English (US)|
|Number of pages||4|
|Publication status||Published - May 6 2002|
- Blood pressure
- Hypertension, essential
ASJC Scopus subject areas
- Internal Medicine