Impaired stress-induced pressure natriuresis is related to left ventricle structure in blacks

Gregory A Harshfield, Frank A. Treiber, Harry Davis, Kakota Gaston Kapuku

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The mechanisms through which stress may contribute to the racial difference in the prevalence of essential hypertension and associated target organ damage remain unclear. This study examined differences in stress-induced pressure natriuresis in 69 black and 52 white normotensives age 14 to 27 years, all with a positive family history of hypertension. Urine samples for sodium excretion were collected before and after a series of tasks (video game challenge, forehead cold stimulation). The average blood pressure across the 2 tasks and the average increase in blood pressure to the 2 tasks were calculated. Blacks had higher mean systolic (131 ± 12 versus 126 ± 12 mm Hg, P<0.02) and diastolic (77 ± 8 versus 72 ± 9 mm Hg, P<0.001) blood pressure and a greater average change in systolic blood pressure (15 ± 9 versus 11 ± 7 mm Hg, P<0.04). This was associated with a smaller change in sodium excretion (2 ± 6 versus 7 ± 10 mEq/h, P<0.002). The change in sodium excretion was related to the change in systolic (r=0.31, P<0.03) and diastolic (r=0.27, P<0.05) blood pressure in whites but not in blacks. Relative wall thickness was greater in blacks (0.31 ± 0.04 versus 0.29 ± 0.03, P<0.002). In conclusion, impaired stress-induced pressure natriuresis in blacks may contribute to racial differences in essential hypertension and its sequelae.

Original languageEnglish (US)
Pages (from-to)844-847
Number of pages4
JournalHypertension
Volume39
Issue number4
DOIs
StatePublished - May 6 2002

Fingerprint

Natriuresis
Heart Ventricles
Blood Pressure
Pressure
Sodium
Video Games
Forehead
Urine
Hypertension

Keywords

  • Blood pressure
  • Echocardiography
  • Hypertension, essential
  • Race
  • Sodium
  • Stress

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Impaired stress-induced pressure natriuresis is related to left ventricle structure in blacks. / Harshfield, Gregory A; Treiber, Frank A.; Davis, Harry; Kapuku, Kakota Gaston.

In: Hypertension, Vol. 39, No. 4, 06.05.2002, p. 844-847.

Research output: Contribution to journalArticle

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