Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart

Mitsuhiro Kudo, Yigang Wang, Maqsood A. Wani, Meifeng Xu, Ahmar Ayub, Muhammad Ashraf

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Myocardial infarction may cause sudden cardiac death and heart failure. Adult cardiac myocytes do not replicate due to lack of a substantive pool of precursor, stem, or reserve cells in an adult heart. Ventricular myocytes following myocardial infarction are replaced by fibrous tissue and this leads to congestive heart failure in severe cases. Anversa et al. described that resident cardiac stem cells are present in the heart, and can repair the damaged mycardium by myocyte regeneration. Recent findings suggest the feasibility of cardiac repair using cell transplantation. However, it remains controversial which cell types are the best for cell transplantation in the ischemic heart. In this study, we demonstrate that cultured bone marrow stromal cells (MSCs) and Lin- bone marrow cells upon transplantation differentiate into myocytes and endothelial cells in the ischemic heart, eventually reducing both infarct size and fibrosis.

Original languageEnglish (US)
Pages (from-to)1113-1119
Number of pages7
JournalJournal of molecular and cellular cardiology
Volume35
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

Bone Marrow Cells
Infarction
Fibrosis
Stem Cells
Muscle Cells
Heart Failure
Cell Transplantation
Myocardial Infarction
Sudden Cardiac Death
Bone Marrow Transplantation
Mesenchymal Stromal Cells
Cardiac Myocytes
Regeneration
Cultured Cells
Endothelial Cells

Keywords

  • Fibrosis
  • Infarction
  • Mouse
  • Myocardium
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. / Kudo, Mitsuhiro; Wang, Yigang; Wani, Maqsood A.; Xu, Meifeng; Ayub, Ahmar; Ashraf, Muhammad.

In: Journal of molecular and cellular cardiology, Vol. 35, No. 9, 01.09.2003, p. 1113-1119.

Research output: Contribution to journalArticle

Kudo, Mitsuhiro ; Wang, Yigang ; Wani, Maqsood A. ; Xu, Meifeng ; Ayub, Ahmar ; Ashraf, Muhammad. / Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. In: Journal of molecular and cellular cardiology. 2003 ; Vol. 35, No. 9. pp. 1113-1119.
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