Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design

Shesh N. Rai; Melissa M. Hudson; Elizabeth McCammon; Laura D Carbone; Francis Tylavsky; Karen Smith; Harriet Surprise; John Shelso; Chin Hon Pui; Sue Kaste

doi:10.1016/j.cct.2008.05.002

Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design

Shesh N. Rai, Melissa M. Hudson, Elizabeth McCammon, Laura D Carbone, Francis Tylavsky, Karen Smith, Harriet Surprise, John Shelso, Chin Hon Pui, Sue Kaste

Rheumatology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The BONEII study is a large two-phase study. The baseline study (Study 1) aims to estimate the prevalence of diminished bone mineral density (BMD) in patients treated for childhood acute lymphoblastic leukemia (ALL) and identify risk factors for BMD deficits. The interventional phase (Study 2) of BONEII has a placebo-controlled double-blind randomized longitudinal design to evaluate the effects of nutritional counseling and calcium and vitamin D supplementation on changes in BMD and serum and urine markers of bone metabolism. The extensive information being collected through this large study will serve as a repository of relational data about BMD and bone turnover and will support further investigations to assess the association of calcium metabolism, bone turnover, nutritional intake, lifestyle factors (such as exercise and the use of alcohol and tobacco), and the specific agents used in ALL therapy in this rapidly increasing population of childhood cancer survivors.

Original language	English (US)
Pages (from-to)	711-719
Number of pages	9
Journal	Contemporary Clinical Trials
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.cct.2008.05.002
State	Published - Sep 2008

Keywords

Acute lymphoblastic leukemia
Bone loss
Bone mineral density
Childhood cancer survivors
Pediatric leukemia
Repeated measures analysis
Skeletal toxicities

ASJC Scopus subject areas

Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cct.2008.05.002

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Rai, S. N., Hudson, M. M., McCammon, E., Carbone, L. D., Tylavsky, F., Smith, K., Surprise, H., Shelso, J., Pui, C. H., & Kaste, S. (2008). Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design. Contemporary Clinical Trials, 29(5), 711-719. https://doi.org/10.1016/j.cct.2008.05.002

Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design. / Rai, Shesh N.; Hudson, Melissa M.; McCammon, Elizabeth et al.
In: Contemporary Clinical Trials, Vol. 29, No. 5, 09.2008, p. 711-719.

Research output: Contribution to journal › Article › peer-review

Rai, SN, Hudson, MM, McCammon, E, Carbone, LD, Tylavsky, F, Smith, K, Surprise, H, Shelso, J, Pui, CH & Kaste, S 2008, 'Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design', Contemporary Clinical Trials, vol. 29, no. 5, pp. 711-719. https://doi.org/10.1016/j.cct.2008.05.002

Rai SN, Hudson MM, McCammon E, Carbone LD, Tylavsky F, Smith K et al. Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design. Contemporary Clinical Trials. 2008 Sep;29(5):711-719. doi: 10.1016/j.cct.2008.05.002

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abstract = "The BONEII study is a large two-phase study. The baseline study (Study 1) aims to estimate the prevalence of diminished bone mineral density (BMD) in patients treated for childhood acute lymphoblastic leukemia (ALL) and identify risk factors for BMD deficits. The interventional phase (Study 2) of BONEII has a placebo-controlled double-blind randomized longitudinal design to evaluate the effects of nutritional counseling and calcium and vitamin D supplementation on changes in BMD and serum and urine markers of bone metabolism. The extensive information being collected through this large study will serve as a repository of relational data about BMD and bone turnover and will support further investigations to assess the association of calcium metabolism, bone turnover, nutritional intake, lifestyle factors (such as exercise and the use of alcohol and tobacco), and the specific agents used in ALL therapy in this rapidly increasing population of childhood cancer survivors.",

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Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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