Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: A single-institution historical experience

Hagop Kantarjian, Susan O'Brien, Elias Jabbour, Guillermo Garcia-Manero, Alfonso Quintas-Cardama, Jenny Shan, Mary Beth Rios, Farhad Ravandi, Stefan Faderl, Tapan Kadia, Gautam Borthakur, Xuelin Huang, Richard Champlin, Moshe Talpaz, Jorge Cortes

Research output: Contribution to journalArticle

210 Scopus citations

Abstract

A total of 1569 patients with chronic myeloid leukemia (CML) referred to our institution within 1 month of diagnosis since 1965 were reviewed: 1148 chronic phase (CP), 175 accelerated phase (AP), and 246 blastic phase (BP). The median survival was 8.9 years in CP, 4.8 years in AP, and 6 months in BP. In CP, the 8-year survival was ≤ 15% before 1983, 42%-65% from 1983-2000, and 87% since 2001. Survival was worse in older patients (P ∇ .004), but this was less significant since 2001 (P ∇ .07). Survival by Sokal risk was significantly different before 2001 (P <.001), but not since 2001 (P ∇ .4). In AP, survival improved over time (P < .001); the 8-year survival in patients treated since 2001 was 75%. Survival by age was not different in years < 2001 (P ∇ .09), but was better since 2001 in patients ≤ 70 years of age (P ∇ .004). In BP, the median survival improved over time (P < .001), although it has been only 7 months since 2001. In summary, survival in CML has significantly improved since 2001, particularly so in CP-AML and AP-CML. Imatinib therapy minimized the impact of known prognostic factors and Sokal risk in CP-CML and accentuated the impact of age in AP- and BP-CML.

Original languageEnglish (US)
Pages (from-to)1981-1987
Number of pages7
JournalBlood
Volume119
Issue number9
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Fingerprint Dive into the research topics of 'Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: A single-institution historical experience'. Together they form a unique fingerprint.

  • Cite this

    Kantarjian, H., O'Brien, S., Jabbour, E., Garcia-Manero, G., Quintas-Cardama, A., Shan, J., Rios, M. B., Ravandi, F., Faderl, S., Kadia, T., Borthakur, G., Huang, X., Champlin, R., Talpaz, M., & Cortes, J. (2012). Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: A single-institution historical experience. Blood, 119(9), 1981-1987. https://doi.org/10.1182/blood-2011-08-358135