Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: Results of a 6-month study

Francesco Orio, Stefano Palomba, Teresa Cascella, Biagio De Simone, Francesco Manguso, Silvia Savastano, Tiziana Russo, Achille Tolino, Fulvio Zullo, Gaetano Lombardi, Ricardo Azziz, Annamaria Colao

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Context: Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients. Objective: The objective of this study was to evaluate the effects of 6 months of metformin administration on endothelial structure and function in women with PCOS. Design: This was a prospective, baseline-controlled, clinical study. Setting: The study was performed at University Federico II (Naples, Italy). Patients: Thirty young normal-weight women with PCOS without additional metabolic or cardiovascular diseases were studied. Interventions: Metformin (850 mg daily) was administered for 6 months. Mean Outcome Measures: The main outcome measures were complete hormonal profile, including total testosterone, SHBG, dehydroepiandrosterone sulfate, prolactin, and gonadotropin levels; serum insulin and glucose levels during a 75-g 2-h oral glucose tolerance test; plasma endothelin-1 concentrations (picomoles per liter ± SD); serum lipid profile; brachial artery baseline diameter (millimeters ± SD), diameter after reactive hyperemia (millimeters ± SD), and flow-mediated dilation (percentage ± SD); and the intima media thickness (millimeters ± SD) on both common carotid arteries. Results: After treatment, SHBG levels and the free androgen index changed significantly (P < 0.001). High-density lipoproteins and the area under curve for glucose/area under curve for insulin ratio also significantly (P < 0.001) increased, whereas low-density lipoproteins and plasma endothelin-1 levels were significantly (P ± 0.001) reduced. No other change was found in any of the biochemical parameters evaluated. A significant difference was observed in brachial artery baseline diameter (3.24 ± 0.30 vs. 3.0 ± 0.30), flow-mediated dilation (14.30±1.90 vs. 15.70±1.50) (P<0.01, each), diameter after reactive hyperemia (3.70±0.30 vs. 3.55±0.10) (P<0.05), and intima media thickness (0.53 ± 0.09 vs. 0.40 ± 0.07) (P < 0.001) after metformin treatment in comparison with baseline values. Conclusions: A 6-month course of metformin improves endothelial structure and function in young, normal-weight women with PCOS.

Original languageEnglish (US)
Pages (from-to)6072-6076
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number11
DOIs
StatePublished - Nov 1 2005

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Polycystic Ovary Syndrome
Metformin
Weights and Measures
Brachial Artery
Hyperemia
Endothelin-1
Glucose
Area Under Curve
Dilatation
Cardiovascular Diseases
Outcome Assessment (Health Care)
Insulin
Plasmas
Therapeutics
Dehydroepiandrosterone Sulfate
Common Carotid Artery
Metabolic Diseases
HDL Lipoproteins
Glucose Tolerance Test
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome : Results of a 6-month study. / Orio, Francesco; Palomba, Stefano; Cascella, Teresa; De Simone, Biagio; Manguso, Francesco; Savastano, Silvia; Russo, Tiziana; Tolino, Achille; Zullo, Fulvio; Lombardi, Gaetano; Azziz, Ricardo; Colao, Annamaria.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 11, 01.11.2005, p. 6072-6076.

Research output: Contribution to journalArticle

Orio, F, Palomba, S, Cascella, T, De Simone, B, Manguso, F, Savastano, S, Russo, T, Tolino, A, Zullo, F, Lombardi, G, Azziz, R & Colao, A 2005, 'Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: Results of a 6-month study', Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 11, pp. 6072-6076. https://doi.org/10.1210/jc.2005-0965
Orio, Francesco ; Palomba, Stefano ; Cascella, Teresa ; De Simone, Biagio ; Manguso, Francesco ; Savastano, Silvia ; Russo, Tiziana ; Tolino, Achille ; Zullo, Fulvio ; Lombardi, Gaetano ; Azziz, Ricardo ; Colao, Annamaria. / Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome : Results of a 6-month study. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 11. pp. 6072-6076.
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abstract = "Context: Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients. Objective: The objective of this study was to evaluate the effects of 6 months of metformin administration on endothelial structure and function in women with PCOS. Design: This was a prospective, baseline-controlled, clinical study. Setting: The study was performed at University Federico II (Naples, Italy). Patients: Thirty young normal-weight women with PCOS without additional metabolic or cardiovascular diseases were studied. Interventions: Metformin (850 mg daily) was administered for 6 months. Mean Outcome Measures: The main outcome measures were complete hormonal profile, including total testosterone, SHBG, dehydroepiandrosterone sulfate, prolactin, and gonadotropin levels; serum insulin and glucose levels during a 75-g 2-h oral glucose tolerance test; plasma endothelin-1 concentrations (picomoles per liter ± SD); serum lipid profile; brachial artery baseline diameter (millimeters ± SD), diameter after reactive hyperemia (millimeters ± SD), and flow-mediated dilation (percentage ± SD); and the intima media thickness (millimeters ± SD) on both common carotid arteries. Results: After treatment, SHBG levels and the free androgen index changed significantly (P < 0.001). High-density lipoproteins and the area under curve for glucose/area under curve for insulin ratio also significantly (P < 0.001) increased, whereas low-density lipoproteins and plasma endothelin-1 levels were significantly (P ± 0.001) reduced. No other change was found in any of the biochemical parameters evaluated. A significant difference was observed in brachial artery baseline diameter (3.24 ± 0.30 vs. 3.0 ± 0.30), flow-mediated dilation (14.30±1.90 vs. 15.70±1.50) (P<0.01, each), diameter after reactive hyperemia (3.70±0.30 vs. 3.55±0.10) (P<0.05), and intima media thickness (0.53 ± 0.09 vs. 0.40 ± 0.07) (P < 0.001) after metformin treatment in comparison with baseline values. Conclusions: A 6-month course of metformin improves endothelial structure and function in young, normal-weight women with PCOS.",
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T1 - Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome

T2 - Results of a 6-month study

AU - Orio, Francesco

AU - Palomba, Stefano

AU - Cascella, Teresa

AU - De Simone, Biagio

AU - Manguso, Francesco

AU - Savastano, Silvia

AU - Russo, Tiziana

AU - Tolino, Achille

AU - Zullo, Fulvio

AU - Lombardi, Gaetano

AU - Azziz, Ricardo

AU - Colao, Annamaria

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Context: Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients. Objective: The objective of this study was to evaluate the effects of 6 months of metformin administration on endothelial structure and function in women with PCOS. Design: This was a prospective, baseline-controlled, clinical study. Setting: The study was performed at University Federico II (Naples, Italy). Patients: Thirty young normal-weight women with PCOS without additional metabolic or cardiovascular diseases were studied. Interventions: Metformin (850 mg daily) was administered for 6 months. Mean Outcome Measures: The main outcome measures were complete hormonal profile, including total testosterone, SHBG, dehydroepiandrosterone sulfate, prolactin, and gonadotropin levels; serum insulin and glucose levels during a 75-g 2-h oral glucose tolerance test; plasma endothelin-1 concentrations (picomoles per liter ± SD); serum lipid profile; brachial artery baseline diameter (millimeters ± SD), diameter after reactive hyperemia (millimeters ± SD), and flow-mediated dilation (percentage ± SD); and the intima media thickness (millimeters ± SD) on both common carotid arteries. Results: After treatment, SHBG levels and the free androgen index changed significantly (P < 0.001). High-density lipoproteins and the area under curve for glucose/area under curve for insulin ratio also significantly (P < 0.001) increased, whereas low-density lipoproteins and plasma endothelin-1 levels were significantly (P ± 0.001) reduced. No other change was found in any of the biochemical parameters evaluated. A significant difference was observed in brachial artery baseline diameter (3.24 ± 0.30 vs. 3.0 ± 0.30), flow-mediated dilation (14.30±1.90 vs. 15.70±1.50) (P<0.01, each), diameter after reactive hyperemia (3.70±0.30 vs. 3.55±0.10) (P<0.05), and intima media thickness (0.53 ± 0.09 vs. 0.40 ± 0.07) (P < 0.001) after metformin treatment in comparison with baseline values. Conclusions: A 6-month course of metformin improves endothelial structure and function in young, normal-weight women with PCOS.

AB - Context: Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients. Objective: The objective of this study was to evaluate the effects of 6 months of metformin administration on endothelial structure and function in women with PCOS. Design: This was a prospective, baseline-controlled, clinical study. Setting: The study was performed at University Federico II (Naples, Italy). Patients: Thirty young normal-weight women with PCOS without additional metabolic or cardiovascular diseases were studied. Interventions: Metformin (850 mg daily) was administered for 6 months. Mean Outcome Measures: The main outcome measures were complete hormonal profile, including total testosterone, SHBG, dehydroepiandrosterone sulfate, prolactin, and gonadotropin levels; serum insulin and glucose levels during a 75-g 2-h oral glucose tolerance test; plasma endothelin-1 concentrations (picomoles per liter ± SD); serum lipid profile; brachial artery baseline diameter (millimeters ± SD), diameter after reactive hyperemia (millimeters ± SD), and flow-mediated dilation (percentage ± SD); and the intima media thickness (millimeters ± SD) on both common carotid arteries. Results: After treatment, SHBG levels and the free androgen index changed significantly (P < 0.001). High-density lipoproteins and the area under curve for glucose/area under curve for insulin ratio also significantly (P < 0.001) increased, whereas low-density lipoproteins and plasma endothelin-1 levels were significantly (P ± 0.001) reduced. No other change was found in any of the biochemical parameters evaluated. A significant difference was observed in brachial artery baseline diameter (3.24 ± 0.30 vs. 3.0 ± 0.30), flow-mediated dilation (14.30±1.90 vs. 15.70±1.50) (P<0.01, each), diameter after reactive hyperemia (3.70±0.30 vs. 3.55±0.10) (P<0.05), and intima media thickness (0.53 ± 0.09 vs. 0.40 ± 0.07) (P < 0.001) after metformin treatment in comparison with baseline values. Conclusions: A 6-month course of metformin improves endothelial structure and function in young, normal-weight women with PCOS.

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