In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications

Tom R. Wendland, Brian S. Muntean, Jaskiran Kaur, Jhindan Mukherjee, Jie Chen, Xinxuan Tan, Dinesh Attygalle, Robert W. Collins, Jon R. Kirchhoff, L. M.Viranga Tillekeratne

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Thiolated o-quinone-capped electrocatalysts modeled on the naturally occurring o-quinone cofactor pyrroloquinoline quinone (PQQ) were designed and synthesized for the development of biosensor devices. The o-quinone-capped electrocatalysts self assembled on gold electrodes through a thiolated phenyleneethynylene linkage to form a monolayer less than 2nm in thickness. Cyclic voltammetric measurements demonstrated reversible electrochemical properties between the quinone and hydroquinone forms of the head group. In an amperometric sensing mode, the modified electrodes reproducibly detected ethanethiol at micromolar levels demonstrating their robust electrocatalytic activity toward thiols. Their redox cycling and electrocatalytic properties show promise for detection of biologically important thiols and other nucleophiles.

Original languageEnglish (US)
Pages (from-to)2275-2279
Number of pages5
JournalElectroanalysis
Volume23
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Amperometric biosensors
  • Electrocatalysts
  • Quinones
  • Self assembly

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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