In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin

John C H Steele, Barbara H. Edwards, John Peter Rissing

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8->32 mg/l).

Original languageEnglish (US)
Pages (from-to)463-468
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume16
Issue number4
DOIs
StatePublished - Oct 1 1985

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Cephalosporins
Bacteria
Methicillin Resistance
Methicillin
Microbial Sensitivity Tests
Enterobacteriaceae
Pseudomonas aeruginosa
Staphylococcus aureus
Range of data
cefepime
In Vitro Techniques

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Microbiology

Cite this

In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin. / Steele, John C H; Edwards, Barbara H.; Rissing, John Peter.

In: Journal of Antimicrobial Chemotherapy, Vol. 16, No. 4, 01.10.1985, p. 463-468.

Research output: Contribution to journalArticle

Steele, John C H ; Edwards, Barbara H. ; Rissing, John Peter. / In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin. In: Journal of Antimicrobial Chemotherapy. 1985 ; Vol. 16, No. 4. pp. 463-468.
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